Results 21 to 30 of about 59,132 (312)

Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors [PDF]

, 2014
Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. The development of inhibitors of the RND pumps would improve the efficacy of current and next-
Nguyen, ST, Nikaido, H, Opperman, TJ, Ruggerone, P, Vargiu, AV   +4 more
core   +2 more sources

Molecular similarity of MDR inhibitors [PDF]

, 2004
Everyone is free to re-use the published material if proper accreditation/citation of the original publication is given. http://creativecommons.org/licences/by/3.0/The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the ...
Gibbons, S., Zloh, Mire
core   +2 more sources

Correlation of ciprofloxacin resistance with the AdeABC efflux system in Acinetobacter baumannii clinical isolates [PDF]

, 2014
Background: Acinetobacter baumannii is one of the most important pathogens capable of colonization in burn patients, leading to drug-resistant wound infections.
Ardebili, A., Lari, A.R., Talebi, M.
core   +1 more source

Clinically Approved Drugs Inhibit the Staphylococcus aureus Multidrug NorA Efflux Pump and Reduce Biofilm Formation

Frontiers in Microbiology, 2019
Staphylococcus aureus has acquired resistance to antibiotics since their first use. The S. aureus protein NorA, an efflux pump belonging to the major facilitator superfamily (MFS), contributes to resistance to fluoroquinolones (e.g., ciprofloxacin ...
Saskia Zimmermann, Saskia Zimmermann, Mareike Klinger-Strobel, Jürgen A. Bohnert, Jürgen A. Bohnert, Sindy Wendler, Jürgen Rödel, Mathias W. Pletz, Bettina Löffler, Bettina Löffler, Lorena Tuchscherr, Lorena Tuchscherr   +11 more
doaj   +1 more source

Transcriptome assembly and profiling of Candida auris reveals novel insights into biofilm-mediated resistance [PDF]

, 2018
Candida auris has emerged as a significant global nosocomial pathogen. This is primarily due to its antifungal resistance profile but also its capacity to form adherent biofilm communities on a range of clinically important substrates.
Ben-Ami, Berkow, Berkow, Bizerra, Bongomin, Borman, Borman, Calvo, Chatterjee, Chowdhary, Defosse, Denning, Dominguez, Fisher, Fonseca, Fox, Fu, Grahl, Haas, Hager, Hashemi, Hunter, Jeffery-Smith, Kean, Kean, Kean, Kean, Kempf, Kordalewska, Kordalewska, Larkin, Liu, Liu, Lockhart, Lohse, Martínez, Mukherjee, Naglik, Naglik, Nailis, Nobile, Perfect, Pierce, Rajendran, Rajendran, Rajendran, Ramage, Ramage, Ramage, Rodrigues, Ruiz-Gaitán, Schelenz, Sherry, Sherry, Silva, Soldini, Taff, Taff, Tumbarello, Tunney, Winter, Zarnowski, Zhao, Zhao   +63 more
core   +4 more sources

Role of efflux pump inhibitor in decreasing antibiotic cross-resistance of Pseudomonas aeruginosa in a burn hospital in Iran

Journal of Infection in Developing Countries, 2016
Introduction: Multidrug resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression. This study phenotypically examined the role of efflux pump inhibitors in decreasing antibiotic cross-resistance between beta-lactams, fluoroquinolones,
Mahshid Talebi-Taher, َAli Majidpour, Abbas Gholami, Samira Rasouli-Kouhi, Maryam Adabi   +4 more
doaj   +1 more source

Efflux Pump Activity and Mutations Driving Multidrug Resistance in Acinetobacter baumannii at a Tertiary Hospital in Pretoria, South Africa

International Journal of Microbiology, 2021
Acinetobacter baumannii (A. baumannii) has developed several resistance mechanisms. The bacteria have been reported as origin of multiple outbreaks. This study aims to investigate the use of efflux pumps and quinolone resistance-associated genotypic ...
Noel-David Nogbou, Granny M. Nkawane, Khanyisa Ntshane, Charles K. Wairuri, Dikwata T. Phofa, Kagiso K. Mokgokong, Mbudzeni Ramashia, Maphoshane Nchabeleng, Lawrence C. Obi, Andrew M. Musyoki   +9 more
doaj   +1 more source

Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]

, 2017
The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R, Gomez, Marcella M, Kalvapalle, Prashant, O'Brien-Gilbert, Erin, Perez, Anisha M, Shamoo, Yousif   +5 more
core   +2 more sources

Efflux Pumps and These Inhibitors

VNU Journal of Science: Medical and Pharmaceutical Sciences, 2019
 In this era of multi-drug resistance, efflux pump is one of the major problems which is increasingly concerned by scientists. The structure and mechanism activity of the efflux pumps on both bacteria and eurakyotes that are gradually being clarified. Since then, efflux pump inhibitors have also been studied and initially applied in clinic, that makes ...
Le Minh Tri, Nguyen Hoang Minh, Hoang Tung, Do Tran Giang Son, Phan Thien Vy, Tran Thanh Dao, Thai Khac Minh   +6 more
openaire   +2 more sources

Inhibition of Staphylococcus pseudintermedius Efflux Pumps by Using Staphylococcus aureus NorA Efflux Pump Inhibitors

Antibiotics, 2023
One promising approach in treating antibiotic-resistant bacteria is to “break” resistances connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with antibiotics. Here, ten compounds, previously optimized to restore the susceptibility to ciprofloxacin (CIP) of norA-overexpressing Staphylococcus aureus, were evaluated for
Rampacci, Elisa, Felicetti, Tommaso, Cernicchi, Giada, Stefanetti, Valentina, Sabatini, Stefano, Passamonti, Fabrizio   +5 more
openaire   +4 more sources