Results 21 to 30 of about 59,758 (308)
Microbiology Spectrum, 2023 NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal +6 more
doaj +1 more source
A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. [PDF]
PLoS Pathogens, 2018 Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug resistant (MDR) pathogens; chemicals that inhibit efflux pumps may have potential for antibiotic ...
Abigail L Reens +8 more
doaj +1 more source
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors [PDF]
, 2014 Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. The development of inhibitors of the RND pumps would improve the efficacy of current and next-
Nguyen, ST +4 more
core +2 more sources
The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria [PDF]
, 2008 Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
A Baslé +95 more
core +1 more source
Correlation of ciprofloxacin resistance with the AdeABC efflux system in Acinetobacter baumannii clinical isolates [PDF]
, 2014 Background: Acinetobacter baumannii is one of the most important pathogens capable of colonization in burn patients, leading to drug-resistant wound infections.
Ardebili, A., Lari, A.R., Talebi, M.
core +1 more source
Frontiers in Microbiology, 2019 Staphylococcus aureus has acquired resistance to antibiotics since their first use. The S. aureus protein NorA, an efflux pump belonging to the major facilitator superfamily (MFS), contributes to resistance to fluoroquinolones (e.g., ciprofloxacin ...
Saskia Zimmermann +11 more
doaj +1 more source
Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]
, 2017 The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R +5 more
core +2 more sources
Journal of Infection in Developing Countries, 2016 Introduction: Multidrug resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression. This study phenotypically examined the role of efflux pump inhibitors in decreasing antibiotic cross-resistance between beta-lactams, fluoroquinolones,
Mahshid Talebi-Taher +4 more
doaj +1 more source
International Journal of Microbiology, 2021 Acinetobacter baumannii (A. baumannii) has developed several resistance mechanisms. The bacteria have been reported as origin of multiple outbreaks. This study aims to investigate the use of efflux pumps and quinolone resistance-associated genotypic ...
Noel-David Nogbou +9 more
doaj +1 more source
Prevalence of QoI resistance and mtDNA diversity in the Irish Zymoseptoria tritici population [PDF]
, 2019 peer-reviewedThe emergence and spread of Quinone outside Inhibitor (QoI) fungicide resistance in the Irish Zymoseptoria tritici population in the early 2000s had immediate impacts on the efficacy of the entire group of fungicides for the control of ...
Bucar, D.E. +5 more
core +1 more source