Results 71 to 80 of about 59,758 (308)
Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis [PDF]
Molecules, 2010 The active multidrug efflux pump (EP) has been described as one of the mechanisms involved in the natural drug resistance of bacteria, such as mycobacteria. As a result, the development of efflux pumps inhibitors (EPIs) is an important topic. In this study, a checkerboard synergy assay indicated that farnesol both decreased the minimum inhibitory ...
Jing Jin +10 more
openaire +3 more sources
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Microbiology SpectrumCurrently, drug resistance is a formidable obstacle to tuberculosisprevention globally. A deep understanding of the drug-resistance mechanism of Mycobacterium tuberculosis is helpful to deal with this problem.
Ying Long +6 more
doaj +1 more source
Efflux pump inhibitors for bacterial pathogens
Indian Journal of Medical Research, 2019 With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics. Antibiotic efflux is one of the major mechanisms, whereby bacteria pump out the antibiotics from their cellular ...
Sharma, Atin +2 more
openaire +2 more sources
Inhibitors of Bacterial Multidrug Efflux Pumps Potentiate Antimicrobial Photoinactivation [PDF]
Antimicrobial Agents and Chemotherapy, 2008 ABSTRACT Antimicrobial photodynamic inactivation (APDI) combines a nontoxic photoactivatable dye or photosensitizer (PS) with harmless visible light to generate singlet oxygen and reactive oxygen species that kill microbial cells.
George P, Tegos +5 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source
Frontiers in Microbiology, 2019 Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance.
Jiayun Liu +9 more
doaj +1 more source
Microbiology, 2023 The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level. The treatment options against infections caused by multiple drug-resistant bacteria are shrinking gradually. The current pace of the discovery of new antibacterial entities is lagging behind the rate of development of new resistance.
Amit Gaurav +4 more
openaire +2 more sources
Triblock Polymer Engineering Enables Hydration‐Rich, High‐Performance, Fouling‐Resistant Interfaces
Advanced Functional Materials, EarlyView.A molecularly engineered triblock polymer (PHZ) rapidly reorganizes into a hydration‐rich interfacial layer on diverse surfaces, strongly suppressing hydrophobic attraction and fouling. The triblock polymer provides robust energy and steric barriers to oily foulants, enabling high‐performance antifouling at ultralow dosage.
Chenyu Qiao +6 more
wiley +1 more source
Drugs and Drug Candidates, 2023 The high frequency of infectious diseases has spurred research into effective tactics to combat microorganisms that are resistant to several drugs.
Samara Barbosa de Brito +13 more
doaj +1 more source