Results 71 to 80 of about 59,132 (312)
Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance. Otherwise, we may go back to the pre-antibiotic era and have no drugs on which to rely.
Lan Zhang +6 more
openaire +3 more sources
Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis [PDF]
Molecules, 2010 The active multidrug efflux pump (EP) has been described as one of the mechanisms involved in the natural drug resistance of bacteria, such as mycobacteria. As a result, the development of efflux pumps inhibitors (EPIs) is an important topic. In this study, a checkerboard synergy assay indicated that farnesol both decreased the minimum inhibitory ...
Jing Jin +10 more
openaire +3 more sources
Triblock Polymer Engineering Enables Hydration‐Rich, High‐Performance, Fouling‐Resistant Interfaces
Advanced Functional Materials, EarlyView.A molecularly engineered triblock polymer (PHZ) rapidly reorganizes into a hydration‐rich interfacial layer on diverse surfaces, strongly suppressing hydrophobic attraction and fouling. The triblock polymer provides robust energy and steric barriers to oily foulants, enabling high‐performance antifouling at ultralow dosage.
Chenyu Qiao +6 more
wiley +1 more source
Microbiology SpectrumCurrently, drug resistance is a formidable obstacle to tuberculosisprevention globally. A deep understanding of the drug-resistance mechanism of Mycobacterium tuberculosis is helpful to deal with this problem.
Ying Long +6 more
doaj +1 more source
Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib [PDF]
, 2009 <p><b>Objective:</b> To investigate the interaction of imatinib mesylate (IM) with the clinically relevant adenosine triphosphate-binding cassette efflux transporter MDR1 (ABCB1) in cells from patients with chronic myeloid leukemia (CML)
Hatziieremia, S. +4 more
core +1 more source
Efflux pump inhibitors for bacterial pathogens
Indian Journal of Medical Research, 2019 With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics. Antibiotic efflux is one of the major mechanisms, whereby bacteria pump out the antibiotics from their cellular ...
Sharma, Atin +2 more
openaire +2 more sources
Inhibitors of Bacterial Multidrug Efflux Pumps Potentiate Antimicrobial Photoinactivation [PDF]
Antimicrobial Agents and Chemotherapy, 2008 ABSTRACT Antimicrobial photodynamic inactivation (APDI) combines a nontoxic photoactivatable dye or photosensitizer (PS) with harmless visible light to generate singlet oxygen and reactive oxygen species that kill microbial cells.
George P, Tegos +5 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Frontiers in Microbiology, 2019 Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance.
Jiayun Liu +9 more
doaj +1 more source
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. [PDF]
, 2008 Objective: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCa agonist.
Beuers, U. +5 more
core +1 more source