Results 101 to 110 of about 54,733 (297)
Advanced Materials, EarlyView.The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li +19 more
wiley +1 more source
Enhancement of antibiotic efficacy against multi-drug resistant Pseudomonas aeruginosa infections via combination with curcumin and 1-(1-Naphthylmethyl)-Piperazine [PDF]
, 2016 Objective: The aim of this study was to determine if the plant phenolic curcumin (CUR) and the arylpiperazine 1-(1-naphthylmethyl)-piperazine (NMP) could restore antibiotic efficacy versus MDR P. aeruginosa infection.
Ballard, E, Coote, Peter John
core +1 more source
A High Throughput Microfluidic Approach for the Continuous Manufacture of Ibuprofen Nanocrystals
Advanced Materials Technologies, EarlyView.A robust, continuous manufacturing platform using a high‐throughput microfluidic reactor addresses key scalability challenges in pharmaceutical production. This process efficiently generates crystalline ibuprofen nanoparticles with superior control over size and distribution.
Shorooq Abukhamees +5 more
wiley +1 more source
Efflux Pump Mediated Streptococcus Mutans Resistance To Quaternary Ammonium Salt
International Dental JournalAim or purpose: The goals of this study were to explore the mechanisms of Streptococcus mutans (S. mutans) resistance to quaternary ammonium salt (QAS), dimethylaminohexadecyl methacrylate (DMAHDM). Materials and methods: Drug-resistance of S.
Yingxiang Chen +6 more
doaj +1 more source
Cholesterol acquisition by Mycobacterium tuberculosis [PDF]
, 2015 In this issue of Virulence, Ramon-Garcia et al. demonstrate the requirement of a mycobacterial efflux pump during growth on cholesterol.
Larrouy-Maumus, GJ
core +1 more source
BLOC: Buildable and Linkable Organ on a Chip
Advanced Materials Technologies, EarlyView.We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura +7 more
wiley +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Frontiers in Microbiology, 2018 We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on efflux pump inhibitors. Using
Renee M. Fleeman +8 more
doaj +1 more source
Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.
Anticancer research, 2012 Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well ...
Amaral, Leonard +6 more
openaire +2 more sources
Advanced Science, EarlyView.This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen +11 more
wiley +1 more source