Efflux Pump Inhibitors Against Nontuberculous Mycobacteria. [PDF]
Int J Mol Sci, 2020 Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus ...
Rindi L.
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Efflux pump inhibitors for bacterial pathogens: From bench to bedside. [PDF]
Indian J Med Res, 2019 With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics.
Sharma A, Gupta VK, Pathania R.
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Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors. [PDF]
Molecules, 2019 Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials.
Mosolygó T +10 more
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Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli. [PDF]
Biology (Basel), 2022 Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-negative bacteria, have posed serious health issues worldwide.
Alenazy R.
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Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives. [PDF]
Molecules, 2021 Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it represents a hot topic in drug discovery. The use of non-antibiotic molecules to block resistance mechanisms is a powerful alternative to the identification of new ...
Cernicchi G, Felicetti T, Sabatini S.
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Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors. [PDF]
Pharmaceuticals (Basel), 2021 The overexpression of efflux pumps is one of the causes of multidrug resistance, which leads to the inefficacy of drugs. This plays a pivotal role in antimicrobial resistance, and the most notable pumps are the AcrAB-TolC system (AcrB belongs to the ...
Durães F +11 more
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Quinazoline Derivatives Designed as Efflux Pump Inhibitors: Molecular Modeling and Spectroscopic Studies. [PDF]
Molecules, 2021 Multidrug resistance of bacteria is a worrying concern in the therapeutic field and an alternative method to combat it is designing new efflux pump inhibitors (EPIs). This article presents a molecular study of two quinazoline derivatives, labelled BG1189
Udrea AM +3 more
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Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification. [PDF]
J Pharm Anal, 2020 The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The major factor in MDR is efflux pump-mediated resistance.
Seukep AJ +4 more
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Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold. [PDF]
Biochim Biophys Acta Gen Subj, 2020 Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the efficacy of existing antibiotics.
Green AT +6 more
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Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. [PDF]
Molecules, 2020 Therapeutic treatment options for opportunistic non-tuberculous mycobacterial (NTM) infection and/or serious mycobacterial infections such as tuberculosis (TB) and leprosy are limited due to the spread of antimicrobial resistance mechanism. Plant-derived
Solnier J, Martin L, Bhakta S, Bucar F.
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