Results 21 to 30 of about 147,157 (321)

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-Negative (ESKAPEE) Bacteria. [PDF]

Antibiotics (Basel), 2019
Antibiotic resistance represents a significant threat to the modern healthcare provision. The ESKAPEE pathogens (Enterococcus faecium., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.
Reza A, Sutton JM, Rahman KM.
europepmc   +2 more sources

Repurposing bioactive aporphine alkaloids as efflux pump inhibitors. [PDF]

Fitoterapia, 2019
Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with efflux pump inhibitors may help to restore the activities of such ...
F. Avci, Basak Atas, C. Aksoy, Eldin Kurpejović, G. G. Toplan, C. Gurer, Maxime Guillerminet, C. Orelle, J. Jault, B. S. Akbulut   +9 more
semanticscholar   +6 more sources

The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors.

Journal of Global Antimicrobial Resistance, 2020
BACKGROUND AND OBJECTIVE Efflux pumps are transmembrane proteins associated with bacterial resistance mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular medium, preventing the pharmacological action of these ...
Cícera Datiane de Morais Oliveira-Tintino, Débora Feitosa Muniz, Cristina Rodrigues Dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, L. E. da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, J. Ribeiro-Filho, Saulo Relison Tintino, I. D. de Menezes, H. M. Melo Coutinho, T. G. da Silva   +18 more
semanticscholar   +4 more sources

Inhibition of Staphylococcus pseudintermedius Efflux Pumps by Using Staphylococcus aureus NorA Efflux Pump Inhibitors. [PDF]

Antibiotics (Basel), 2023
One promising approach in treating antibiotic-resistant bacteria is to “break” resistances connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with antibiotics. Here, ten compounds, previously optimized to restore the susceptibility to ciprofloxacin (CIP) of norA-overexpressing Staphylococcus aureus, were evaluated for
Rampacci E, Felicetti T, Cernicchi G, Stefanetti V, Sabatini S, Passamonti F.   +5 more
europepmc   +5 more sources

Flavonoids as Inhibitors of Bacterial Efflux Pumps [PDF]

Molecules, 2021
Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances.
Martin Waditzer, Franz Bucar
openaire   +3 more sources

Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica

Brazilian Journal of Infectious Diseases, 2013
Objectives: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree ...
Abeer Ahmed Rushdy, Mona Ibrahim Mabrouk, Ferialla Abdel-Hamid Abu-Sef, Zeinab Hassan Kheiralla, Said Mohamed Abdel -All, Neveen Mohamed Saleh   +5 more
doaj   +3 more sources

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

Microbiology Spectrum, 2023
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar   +6 more
doaj   +1 more source

Bacterial efflux pump inhibitors from natural sources [PDF]

Journal of Antimicrobial Chemotherapy, 2006
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus ...
Stavri, Michael, Piddock, Laura J. V., Gibbons, Simon   +2 more
openaire   +3 more sources

Detection of tetracyclines and efflux pump inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 1993
Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein, M, McGlynn, V, Bernan, J, McGahren, J, Zaccardi, N, Cekleniak, K P, Bertrand   +6 more
openaire   +2 more sources

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Frontiers in Microbiology, 2021
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino, Seiji Yamasaki, Ryosuke Nakashima, Martijn Zwama, Mitsuko Hayashi-Nishino   +4 more
doaj   +1 more source