Results 41 to 50 of about 147,157 (321)

Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition

Antibiotics, 2021
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major health threat worldwide due to significant morbidity and mortality resulting from their associated hospital- or community-acquired infections. Dramatic decrease in
Abolfazl Dashtbani-Roozbehani, Melissa H. Brown   +1 more
doaj   +1 more source

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

Selenocompounds as Potent Efflux Pump Inhibitors on Gram-positive Bacteria. [PDF]

ChemMedChem
AbstractIn recent years, selenocompounds have gained increasing attention as potential anticancer and antibacterial agents. Several selenoderivatives have been confirmed to act as MDR efflux pump inhibitors, based on their in vitro results against the bacterial AcrAB‐TolC system and the cancer MDR efflux pump P‐glycoprotein. Efflux pumps can contribute
Kincses A, Szemerédi N, Benito-Lama M, Dózsai D, Csonka Á, Domínguez-Álvarez E, Spengler G.   +6 more
europepmc   +5 more sources

Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa

mBio, 2021
Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps ...
Jitender Mehla, Giuliano Malloci, Rachael Mansbach, Cesar A. López, Ruslan Tsivkovski, Keith Haynes, Inga V. Leus, Sally B. Grindstaff, Robert H. Cascella, Napoleon D’Cunha, Liam Herndon, Nicolas W. Hengartner, Enrico Margiotta, Alessio Atzori, Attilio V. Vargiu, Pedro D. Manrique, John K. Walker, Olga Lomovskaya, Paolo Ruggerone, S. Gnanakaran, Valentin V. Rybenkov, Helen I. Zgurskaya   +21 more
doaj   +1 more source

The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis [PDF]

, 2017
Tuberculosis (TB) is currently the number one killer among infectious diseases worldwide. Lipids are abundant molecules during the infectious cycle of Mycobacterium tuberculosis (Mtb) and studies better mimicking its actual metabolic state during ...
Aguilar-Ayala, Diana, Deforce, Dieter, Gonzalez-Y-Merchand, Jorge A, Martin, Anandi, Palomino, Juan Carlos, Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Vandamme, Peter   +7 more
core   +2 more sources

Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues

Pharmaceuticals, 2020
Multidrug resistance of cancer cells to cytotoxic drugs still remains a major obstacle to the success of chemotherapy in cancer treatment. The development of new drug candidates which may serve as P-glycoprotein (P-gp) efflux pump inhibitors is a ...
Małgorzata Anna Marć, Annamária Kincses, Bálint Rácz, Muhammad Jawad Nasim, Muhammad Sarfraz, Carlos Lázaro-Milla, Enrique Domínguez-Álvarez, Claus Jacob, Gabriella Spengler, Pedro Almendros   +9 more
doaj   +1 more source

Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]

PLoS ONE, 2013
BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot, Mélanie Monique Lopez, Thomas Poyot, Fabienne Neulat-Ripoll, Sabrina Lignon, Arnaud Caclard, François Michel Thibault, Andre Peinnequin, Jean-Marie Pagès, Eric Valade   +9 more
doaj   +1 more source

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

Efflux Pumps and These Inhibitors

VNU Journal of Science: Medical and Pharmaceutical Sciences, 2019
 In this era of multi-drug resistance, efflux pump is one of the major problems which is increasingly concerned by scientists. The structure and mechanism activity of the efflux pumps on both bacteria and eurakyotes that are gradually being clarified. Since then, efflux pump inhibitors have also been studied and initially applied in clinic, that makes ...
Le Minh Tri, Nguyen Hoang Minh, Hoang Tung, Do Tran Giang Son, Phan Thien Vy, Tran Thanh Dao, Thai Khac Minh   +6 more
openaire   +2 more sources

A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.

PLoS ONE, 2015
Bacterial efflux pumps are active transport proteins responsible for resistance to selected biocides and antibiotics. It has been shown that production of efflux pumps is up-regulated in a number of highly pathogenic bacteria, including methicillin ...
Adam R Brown, Keivan A Ettefagh, Daniel Todd, Patrick S Cole, Joseph M Egan, Daniel H Foil, Tyler N Graf, Bryan D Schindler, Glenn W Kaatz, Nadja B Cech   +9 more
doaj   +1 more source