Results 71 to 80 of about 147,157 (321)
ChemMedChem, 2020 2‐aminothiophene derivatives (2AT) in which the thiophene ring is fused with a cycloalkyl or a N‐acylated piperidine ring by positions 5 and 6 and carrying a 3‐carbethoxy group were synthesized and their bacterial growth and enzyme inhibitory effects ...
Rayssa M. D. Cruz +7 more
semanticscholar +1 more source
Diversity of Listeria monocytogenes strains of clinical and food chain origins in Belgium between 1985 and 2014 [PDF]
, 2016 Listeriosis is a rare but severe disease, mainly caused by Listeria monocytogenes. This study shows the results of the laboratory-based surveillance of Listeriosis in Belgium over the period 1985-2014.
Bertrand, S +7 more
core +13 more sources
Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates
Frontiers in MicrobiologyAntibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza +12 more
doaj +1 more source
Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]
, 2017 Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef +7 more
core +3 more sources
Expert Review of Anti-Infective Therapy, 2020 Introduction: In 2018, an estimated 377,000 people developed multidrug-resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has been accepted that efflux pumps play an important role in the evolution of drug ...
L. Rodrigues, P. Cravo, M. Viveiros
semanticscholar +1 more source
Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli [PDF]
PeerJ, 2017 Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria.
Diana Machado +8 more
doaj +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
BMC Microbiology, 2011 Background Active efflux systems and reduced cell-wall permeability are considered to be the main causes of mycobacterial intrinsic resistance to many antimicrobials.
Couto Isabel +4 more
doaj +1 more source
Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Lulu Huang +8 more
doaj +1 more source
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter [PDF]
, 1967 Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Brunak, Søren +8 more
core +3 more sources