Results 141 to 150 of about 208,103 (288)
One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections
Advanced Science, EarlyView.Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong +11 more
wiley +1 more source
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Identification of three outer membrane channels of RND efflux pumps.
, 2013 Identification of three outer membrane channels of RND efflux pumps.
Thomas Poyot (135820) +9 more
core +1 more source
Advanced Science, EarlyView.Heteroatom precursor engineering serves as a molecular‐level strategy to tailor hydrazide monomer reactivity and diffusion kinetics, enabling controlled assembly of highly crystalline COF membranes with ultramicroporous channels. The nitrogen‐enriched nanochannels deliver high water/ion selectivity via simultaneous water transport acceleration and ion ...
Guishan Hu +8 more
wiley +1 more source
Advanced Science, EarlyView.Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang +9 more
wiley +1 more source
Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential
mBioEfflux pumps are well known to be an important mechanism for removing noxious substances such as antibiotics from bacteria. Given that many antibiotics function by accumulating inside bacteria, efflux pumps contribute to resistance.
Emily E. Whittle +6 more
doaj +1 more source
Advanced Science, EarlyView.Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley +1 more source
Bacterial antibiotic resistance by efflux pumps [PDF]
, 2011 La resistencia a los antimicrobianos representa un severo problema a nivel mundial. Se han descripto variados mecanismos de resistencia, entre los cuales se encuentran las bombas de eflujo.
Errecalde, Jorge Oscar +2 more
core
Efflux Pumps Role in the Emergence of MDR Bacteria [PDF]
The emergence multidrug tolerance is the most threatening obstacle for the population health. During the last years, transporting pumps are implicated in the emergence of antibiotic resistance.
Jabuk, Sura I.A. +3 more
core +1 more source
Advanced Science, EarlyView.Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai +12 more
wiley +1 more source