Function and Inhibitory Mechanisms of Multidrug Efflux Pumps [PDF]
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Martijn Zwama +2 more
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Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps [PDF]
Antibiotics, 2023 The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps play a noteworthy role because they export extraneous and noxious substrates ...
Concetta Beninati +2 more
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Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview [PDF]
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Xu Wang, Menghong Dai, Guyue Cheng
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Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates [PDF]
Frontiers in MicrobiologyAntibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Jean-Luc Wolfender +2 more
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Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family [PDF]
Frontiers in Molecular Biosciences, 2021 Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of
Martina Pasqua +8 more
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Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants
Microorganisms, 2016 Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels.
Alejandra Bernardini +2 more
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Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence [PDF]
Frontiers in Microbiology, 2016 Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance.
Manuel Alcalde-Rico +3 more
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Tripartite assembly of RND multidrug efflux pumps [PDF]
Nature Communications, 2016 Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic ...
Laetitia Daury +10 more
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Inhibition of Multidrug Efflux Pumps Belonging to the Major Facilitator Superfamily in Bacterial Pathogens [PDF]
Biomedicines, 2023 Manjusha Lekshmi +2 more
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mSystems, 2021 Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or transiently induced by various environmental signals, which are typically ...
Di-Yin Li +7 more
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