Results 31 to 40 of about 262,601 (237)

The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells

Microorganisms, 2019
Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many
Martina Pasqua, Milena Grossi, Alessandro Zennaro, Giulia Fanelli, Gioacchino Micheli, Frederic Barras, Bianca Colonna, Gianni Prosseda   +7 more
doaj   +1 more source

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli

Biology, 2022
Infections caused by multidrug resistance (MDR) of Gram-negative bacteria have become one of the most severe public health problems worldwide. The main mechanism that confers MDR to bacteria is drug efflux pumps, as they expel a wide range of compounds ...
Rawaf Alenazy
doaj   +1 more source

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria [PDF]

, 2010
Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Han Haley, Jacques Vervoort, Alexandre M. J. J. Bonvin, George P Tegos, Lewis Kim, Panagiotis L. Kastritis, Vervoort, J., NMR Spectroscopy, Michael R. Hamblin, Kastritis, P., Vervoort Jacques, Exarchou, Vassiliki, Vervoort, Jacques, Bonvin, A.M., Kastritis Panagiotis L., Hamblin, Michael, Tegos, George, Tegos, George P., Lewis, K., Kim Lewis, George P. Tegos, Bonvin, Alexandre M. J. J., Panagiotis L Kastritis, Bonvin Alexandre M. J. J., Sub NMR Spectroscopy, Han, H., Tegos, G.P., Alexandre M J J Bonvin, Fiamegos Yiannis C., Fiamegos, Y.C., Yiannis C Fiamegos, Kastritis, P.L., Hamblin, Michael R., Exarchou Vassiliki, Lewis, Kim, Exarchou, V., Han, Haley, Hamblin Michael R., Tegos George P., Michael R Hamblin, Fiamegos, Yiannis C., Haley Han, Yiannis C. Fiamegos, Kastritis, Panagiotis L., Vassiliki Exarchou, Bonvin, A.M.J.J., Hamblin, M.R., Vervoort, J.J.M.   +47 more
core   +3 more sources

Functionally cloned pdrM from Streptococcus pneumoniae encodes a Na(+) coupled multidrug efflux pump. [PDF]

PLoS ONE, 2013
Multidrug efflux pumps play an important role as a self-defense system in bacteria. Bacterial multidrug efflux pumps are classified into five families based on structure and coupling energy: resistance-nodulation-cell division (RND), small multidrug ...
Kohei Hashimoto, Wakano Ogawa, Toshihiro Nishioka, Tomofusa Tsuchiya, Teruo Kuroda   +4 more
doaj   +1 more source

The nature and epidemiology of OqxAB, a multidrug efflux pump [PDF]

Antimicrobial Resistance & Infection Control, 2019
OqxAB efflux pump has been found to mediate multidrug resistance (MDR) in various bacteria over the past decades. The updates on the nature and epidemiology of OqxAB efflux pump need to be fully reviewed to broaden our understanding of this MDR determinant.A literature search using the keyword of "oqxAB" was conducted in the online databases of Pubmed ...
Jun Li, Heying Zhang, Jianan Ning, Abdul Sajid, Guyue Cheng, Zonghui Yuan, Haihong Hao   +6 more
openaire   +3 more sources

An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens

Frontiers in Microbiology, 2015
The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable.
Karl A Hassan, Liam DH Elbourne, Liping eLi, Hasinika KA Hewawasam Gamage, Qi eLiu, Scott M Jackson, David eSharples, Anne-Brit eKolstø, Peter JF Henderson, Ian T Paulsen   +9 more
doaj   +1 more source

Roles of SmeYZ, SbiAB, and SmeDEF Efflux Systems in Iron Homeostasis of Stenotrophomonas maltophilia

Microbiology Spectrum, 2022
Stenotrophomonas maltophilia, a nonfermenting Gram-negative rod, is frequently isolated from the environment and is emerging as a multidrug-resistant global opportunistic pathogen. S.
Chao-Jung Wu, Yu Chen, Li-Hua Li, Cheng-Mu Wu, Yi-Tsung Lin, Cheng-Hua Ma, Tsuey-Ching Yang   +6 more
doaj   +1 more source

The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae [PDF]

, 2020
The emergence of multidrug-resistant Klebsiella pneumoniae is a worldwide problem. K. pneumoniae possesses numerous resistant genes in its genome.
Mizusawa, Minako, Ogawa, Wakano, Matsubara, Futoshi, Kitagawa, Ryoko, Kishino, Takanori, Ni, Rui Ting, Onishi, Motoyasu, Tsuchiya, Tomofusa, Kuroda, Teruo   +8 more
core   +2 more sources

Role of H- and D- MATE-type transporters from multidrug resistant clinical isolates of Vibrio fluvialis in conferring fluoroquinolone resistance. [PDF]

PLoS ONE, 2012
BACKGROUND: The study seeks to understand the role of efflux pumps in multidrug resistance displayed by the clinical isolates of Vibrio fluvialis, a pathogen known to cause cholera-like diarrhoea.
Priyabrata Mohanty, Arati Patel, Ashima Kushwaha Bhardwaj   +2 more
doaj   +1 more source

Identification of a multidrug efflux pump inFlavobacterium johnsoniae [PDF]

Veterinary Research, 2009
In this study, the mechanism conferring multiple drug resistance in several strains of flavobacteria isolated from the ovarian fluids of hatchery reared 3-year old brook trout Salvelinus fontinalis was investigated. Metabolic fingerprinting and 16S rRNA gene sequences identified the isolates as Flavobacterium johnsoniae. The isolates exhibited multiple
Clark, Sarah E., Jude, Brooke A., Danner, G. Russell, Fekete, Frank A.   +3 more
openaire   +3 more sources