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Role of bacterial multidrug efflux pumps during infection
World Journal of Microbiology and BiotechnologyMultidrug efflux pumps are protein complexes located in the cell envelope that enable bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for infection. Hence, they are important players in microbial pathogenesis.
Hernando-Amado, Sara +5 more
core +5 more sources
Molecular Dynamics Computer Simulations of Multidrug RND Efflux Pumps [PDF]
Computational and Structural Biotechnology Journal, 2013 Over-expression of multidrug efflux pumps of the Resistance Nodulation Division (RND) protein super family counts among the main causes for microbial resistance against pharmaceuticals.
Kandt C. +14 more
core +5 more sources
On the Structure and Function of Multidrug Efflux Pumps
, 2019 Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to ...
core +4 more sources
Multidrug efflux pumps and their inhibitors characterized by computational modeling
, 2016 Antimicrobial resistance is a key public health concern of our era due to an ever-increasing number of drug-resistant pathogens, including several Gram-negative bacilli.
CACCIOTTO, PIERPAOLO +9 more
core +3 more sources
Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]
International Journal of Molecular Sciences, 2012 Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
openaire +2 more sources
Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
openaire +2 more sources
mSphere, 2023 Pathogen inactivation is a strategy to improve the safety of transfusion products. The only pathogen reduction technology for blood products currently approved in the US utilizes a psoralen compound, called amotosalen, in combination with UVA light to ...
Alex B. Green +10 more
doaj +1 more source
Structure of the AcrAB–TolC multidrug efflux pump [PDF]
Nature, 2014 The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, many of these transporters form multicomponent 'pumps' that span both inner and outer membranes and are driven energetically by a primary or secondary transporter ...
Du, Dijun +8 more
openaire +2 more sources
EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE
Медична наука України, 2023 Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group.
M.V. Khaitovych
doaj +1 more source
Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]
PLoS ONE, 2013 BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot +9 more
doaj +1 more source