Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli [PDF]
Biology, 2022 Infections caused by multidrug resistance (MDR) of Gram-negative bacteria have become one of the most severe public health problems worldwide. The main mechanism that confers MDR to bacteria is drug efflux pumps, as they expel a wide range of compounds ...
Rawaf Alenazy
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Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance [PDF]
mBio, 2020 Neisseria gonorrhoeae is an obligate human pathogen and causative agent of the sexually transmitted infection (STI) gonorrhea. The most predominant and clinically important multidrug efflux system in N.
Meinan Lyu +7 more
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Sodium Malonate Inhibits the AcrAB-TolC Multidrug Efflux Pump of Escherichia coli and Increases Antibiotic Efficacy [PDF]
Pathogens, 2022 There is an urgent need to find novel treatments for combating multidrug-resistant bacteria. Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this problem.
Allea Cauilan, Cristian Ruiz
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In situ structure and assembly of the multidrug efflux pump AcrAB-TolC [PDF]
Nature Communications, 2019 Multidrug efflux pumps actively expel a wide range of toxic substrates from bacteria and play a major role in drug resistance. Here authors show the in situ structure of the efflux pump AcrAB-TolC obtained by electron cryo-tomography and subtomogram ...
Xiaodong Shi +11 more
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An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump [PDF]
eLife, 2017 Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope.
Zhao Wang +8 more
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Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance [PDF]
Microbiology Spectrum, 2023 Campylobacter jejuni is a bacterium that is commonly present in the intestinal tracts of animals. It is also a major foodborne pathogen that causes gastroenteritis in humans.
Zhemin Zhang +6 more
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Function and Inhibitory Mechanisms of Multidrug Efflux Pumps [PDF]
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino +4 more
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Mutational analysis of multidrug efflux pump (AcrAB-TolC) in E nterobacter cloacae isolates from clinical samples [PDF]
Scientific ReportsIn Gram-negative bacterial pathogens, multidrug efflux pump’s role is being studied as one of the critical mechanisms to develop antibiotics resistance. The current study was designed to characterize the AcrAB-TolC efflux pump genes to determine its role
Sajeela Akbar +4 more
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Molecules, 2017 Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials.
Gabriella Spengler +3 more
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Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii. [PDF]
MBio, 2021 Edward W Yu +2 more
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