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Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Lulu Huang +8 more
doaj +1 more source
Multidrug Efflux Pumps in Staphylococcus aureus: an Update [PDF]
The Open Microbiology Journal, 2013 The emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pumps, proteins that cells use to detoxify from noxious compounds, seem to play a key role in the emergence of these ...
Costa, Sofia Santos +3 more
openaire +2 more sources
Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria
Antibiotics, 2021 The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist to the action of a wide range of antibiotics is becoming a growing problem for public health.
Fernando Durães +6 more
doaj +1 more source
Journal of Global Infectious Diseases, 2021 Introduction: Multidrug-resistant Acinetobacter baumannii is galloping, posing threat to tackle, and leaving us with limited options of treatment. Methods: The purpose of this study is to find the genotypic association in drug-resistant A.
Shahid Raza +7 more
doaj +1 more source
RND multidrug efflux pumps: what are they good for? [PDF]
Frontiers in Microbiology, 2013 Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, genes encoding for multidrug efflux ...
Alvarez-Ortega, Carolina +2 more
openaire +4 more sources
Expression and regulation of P-glycoprotein, a multidrug efflux pump, in hematopoietic cells.
, 1993 Expression and regulation of P-glycoprotein, a multidrug efflux pump, in hematopoietic ...
Preet Mohan. Chaudhary (7967717)
core +6 more sources
Journal of Infection in Developing Countries, 2016 Introduction: Multidrug resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression. This study phenotypically examined the role of efflux pump inhibitors in decreasing antibiotic cross-resistance between beta-lactams, fluoroquinolones,
Mahshid Talebi-Taher +4 more
doaj +1 more source
In vitro synergistic effect of amlodipine and imipenem on the expression of the AdeABC efflux pump in multidrug-resistant Acinetobacter baumannii. [PDF]
PLoS ONE, 2018 INTRODUCTION:Multidrug-resistant Acinetobacter baumannii (A. baumannii) has become one of the greatest threats worldwide to the therapeutic management of infections.
Chao Hu +6 more
doaj +1 more source
Frontiers in Microbiology, 2015 The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable.
Karl A Hassan +9 more
doaj +1 more source
Role of the multidrug resistance efflux pump MexCD-OprJ in the Pseudomonas aeruginosa quorum sensing response [PDF]
, 2018 Multidrug efflux pumps constitute a category of antibiotic resistance determinants that are a part of the core bacterial genomes. Given their conservation, it is conceivable that they present functions beyond the extrusion of antibiotics currently used ...
Carolina Alvarez-Ortega +9 more
core +1 more source