Results 21 to 30 of about 462,631 (250)
Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps
Antibiotics, 2023 The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps play a noteworthy role because they export extraneous and noxious substrates ...
Giuseppe Valerio De Gaetano +4 more
doaj +1 more source
Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]
International Journal of Molecular Sciences, 2012 Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
openaire +2 more sources
Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
openaire +2 more sources
Structure of the AcrAB–TolC multidrug efflux pump [PDF]
Nature, 2014 The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, many of these transporters form multicomponent 'pumps' that span both inner and outer membranes and are driven energetically by a primary or secondary transporter ...
Du, Dijun +8 more
openaire +2 more sources
Journal of Medical Microbiology and Infectious Diseases, 2022 Introduction: In the past decade, multidrug-resistant Acinetobacter baumannii has become one of the most critical challenges in treating infected patients. The AdeABC efflux pump is the most important among the various resistance mechanisms. This pump
Amin Sepehr1 +2 more
doaj +1 more source
Tripartite assembly of RND multidrug efflux pumps [PDF]
Nature Communications, 2016 Abstract Tripartite multidrug efflux systems of Gram-negative bacteria are composed of an inner membrane transporter, an outer membrane channel and a periplasmic adaptor protein. They are assumed to form ducts inside the periplasm facilitating drug exit across the outer membrane. Here we present the reconstitution
Daury +11 more
openaire +4 more sources
Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies
Antibiotics, 2021 The RND family efflux pump AcrAB-TolC in E. coli and its homologs in other Gram-negative bacteria are major players in conferring multidrug resistance to the cells.
Prasangi Rajapaksha +5 more
doaj +1 more source
Nature Communications, 2022 Antibiotic resistance through multidrug efflux is a major hurdle in antibiotic development. Here, authors experimentally demonstrate that EmrE, a small multidrug resistance efflux pump from E.
Peyton J. Spreacker +6 more
doaj +1 more source
Multidrug efflux pumps: structure, function and regulation [PDF]
Nature Reviews Microbiology, 2018 Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps.
Du +7 more
openaire +2 more sources
mBio, 2020 The substantial rise in multidrug-resistant bacterial infections is a current global imperative. Cumulative efforts to characterize antimicrobial resistance in bacteria has demonstrated the spread of six families of multidrug efflux pumps, of which ...
Sherif Abouelhadid +4 more
doaj +1 more source