Results 41 to 50 of about 462,631 (250)

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB [PDF]

, 2020
Resistance-nodulation-division efflux pumps play a key role in inherent and evolved multidrug resistance in bacteria. AcrB, a prototypical member of this protein family, extrudes a wide range of antimicrobial agents out of bacteria.
Reading, Eamonn, Lau, Andy, Lau, Andy M., Ricci, Vito, Stone, Jack, Piddock, Laura J.V., Fais, Chiara, Piddock, Laura JV, Politis, Argyris, Wang-Kan, Xuan, Booth, Paula J, Reading, Eamonn; id_orcid, Vargiu, Attilio V, Lau, Andy M, Grimsey, Elizabeth, Booth, Paula, Ahdash, Zainab, Wang Kan, Xuan, Ruggerone, Paolo, Piddock, Laura J V, Malloci, Giuliano, Kan, Xuan Wang, Booth, Paula J., Vargiu, Attilio V., Konijnenberg, Albert, Findlay, Heather   +25 more
core   +3 more sources

Overexpression of the adeB Efflux Pump Gene in Tigecycline-Resistant Acinetobacter baumannii Clinical Isolates and Its Inhibition by (+)Usnic Acid as an Adjuvant

Antibiotics, 2021
Acinetobacter species are among the most life-threatening Gram-negative bacilli, causing hospital-acquired infections, and they are associated with high morbidity and mortality. They show multidrug resistance that acts via various mechanisms.
Nagaraju Bankan, Fathimunnisa Koka, Rajagopalan Vijayaraghavan, Sreekanth Reddy Basireddy, Selvaraj Jayaraman   +4 more
doaj   +1 more source

RND Pump-Mediated Efflux of Amotosalen, a Compound Used in Pathogen Inactivation Technology to Enhance Safety of Blood Transfusion Products, May Compromise Its Gram-Negative Anti-Bacterial Activity

mSphere, 2023
Pathogen inactivation is a strategy to improve the safety of transfusion products. The only pathogen reduction technology for blood products currently approved in the US utilizes a psoralen compound, called amotosalen, in combination with UVA light to ...
Alex B. Green, Lucius Chiaraviglio, Katherine A. Truelson, Katelyn E. Zulauf, Meng Cui, Zhemin Zhang, Matthew P. Ware, Willy A. Flegel, Richard L. Haspel, Edward W. Yu, James E. Kirby   +10 more
doaj   +1 more source

Lipid bilayer composition influences small multidrug transporters [PDF]

, 2008
Background: Membrane proteins are influenced by their surrounding lipids. We investigate the effect of bilayer composition on the membrane transport activity of two members of the small multidrug resistance family; the Escherichia coli transporter, EmrE
Charalambous, K, Curnow, Paul, Curnow, P., Curnow, P, Miller, D, Charalambous, Kalypso, Booth, Paula J, Miller, D., Booth, P.J., Miller, David, Booth, PJ   +10 more
core   +1 more source

Identification of a multidrug efflux pump inMycobacterium smegmatis [PDF]

FEMS Microbiology Letters, 2016
Cell wall impermeability and active efflux of drugs are among the primary reasons for drug resistance in mycobacteria. Efflux pumps are tripartite membrane localized transport proteins that expel drug molecules outside the cells. Several of such efflux pumps are annotated in mycobacteria, but few have been characterized, like MSMEG_2991, a putative ...
Ankita, Bansal, Dhriti, Mallik, Debasish, Kar, Anindya S, Ghosh   +3 more
openaire   +2 more sources

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

mBio, 2019
Resistance-nodulation-cell division multidrug efflux pumps are membrane proteins that catalyze the export of drugs and toxic compounds out of bacterial cells.
Chih-Chia Su, Christopher E. Morgan, Sekhar Kambakam, Malligarjunan Rajavel, Harry Scott, Wei Huang, Corey C. Emerson, Derek J. Taylor, Phoebe L. Stewart, Robert A. Bonomo, Edward W. Yu   +10 more
doaj   +1 more source

Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2007
Acinetobacter baumannii is an opportunistic pathogen, causing infections mainly in patients in intensive care units where the extensive use of antimicrobial agents can select for the emergence of multiresistant strains. In fact, since strains resistant to all antimicrobial agents have been reported, A.
Vila, Jordi, Martí, Sara, Sánchez-Céspedes, Javier   +2 more
openaire   +3 more sources

Possible Role of Curcumin as an Efflux Pump Inhibitor in Multi Drug Resistant Clinical Isolates of Pseudomonas aeruginosa [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Multidrug resistant non-fermenters are continuously increasing in hospital and ICU settings. One of the mechanisms of developing drug resistance is possession of efflux pump through which bacteria extrude antimicrobial agents and other ...
Nidhi Negi, Pradyot Prakash, Mohan Lal Gupta, Tribhuban Mohan Mohapatra   +3 more
doaj   +1 more source

EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE

Медична наука України, 2023
Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group.
M.V. Khaitovych
doaj   +1 more source

Resistance to antimicrobial agents in bifidobacteria [PDF]

, 2005
Includes bibliographical references (leaves 95-106).For bifidobacteria to survive and achieve colonisation, they have to interact with inhibitory host-produced substances such as bile salts.
Price, Claire Emile
core   +1 more source