Results 51 to 60 of about 462,631 (250)

Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates

Frontiers in Microbiology
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza, Léna Mazza, Alexandre Bory, Alexandre Bory, Alexandre Luscher, Alexandre Luscher, Joachim Kloehn, Jean-Luc Wolfender, Jean-Luc Wolfender, Christian van Delden, Christian van Delden, Thilo Köhler, Thilo Köhler   +12 more
doaj   +1 more source

A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters

Antibiotics, 2019
Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the ...
Sandra G. Zárate, Paula Morales, Katarzyna Świderek, Victor M. Bolanos-Garcia, Agatha Bastida   +4 more
doaj   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Molecular Characterization of Moraxella Catarrhalis and it's Antibiotics Susceptibility Patterns from Different Respiratory Tract Infection Patient's Clinical Samples

Journal of College of Medical Sciences-Nepal, 2023
Introduction Moraxella catarrhalis is a gram negative, oxidase positive, cocci mainly causing upper and lower respiratory tract infections. The RND family efflux pumps lead to multidrug resistance in most of the gram negative bacteria.
Brajesh Kumar Jha, Hari Prasad Upadhyay, S Mahadevamurthy, J Sudisha   +3 more
doaj   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Multidrug efflux pumps: drug binding – gates or cavity? [PDF]

The FEBS Journal, 2010
The role of the ATP‐binding cassette ABCB1 in mediating the resistance to chemotherapy in many forms of cancer has been well established. The protein is also endogenously expressed in numerous barrier and excretory tissues, thereby regulating or impacting on drug pharmacokinetic profiles.
Crowley, Emily, Callaghan, Richard
openaire   +3 more sources

Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting RE-CmeB in Campylobacter spp.

One Health Advances
RE-CmeABC is a variant of the efflux pump CmeABC in the major zoonotic pathogen Campylobacter, which is much more potent in conferring resistance to various antibiotics for the treatment of Campylobacter infections in both veterinary and medical clinics.
Shihong Li, Cheng Zhang, Wenjun Li, Shuigen Wan, Jin Kang, Yong Liu, Hexiang Huang, Hao Li, Longhua Yang, Yanhong Shang, Chenglong Li, Xiangdang Du, Hong Yao   +12 more
doaj   +1 more source

Molecular and phenotypic characterization of efflux pump and biofilm in multi-drug resistant non-typhoidal Salmonella Serovars isolated from food animals and handlers in Lagos Nigeria

One Health Outlook, 2021
Background Multidrug resistance efflux pumps and biofilm formation are mechanisms by which bacteria can evade the actions of many antimicrobials. Antibiotic resistant non-typhoidal Salmonella serovars have become wide spread causing infections that ...
Elizabeth Tolulope Olubisose, Abraham Ajayi, Adeyemi Isaac Adeleye, Stella Ifeanyi Smith   +3 more
doaj   +1 more source

Global genomic epidemiology of chromosomally mediated non-enzymatic carbapenem resistance in Acinetobacter baumannii: on the way to predict and modify resistance

Frontiers in Microbiology, 2023
IntroductionAlthough carbapenemases are frequently reported in resistant A. baumannii clinical isolates, other chromosomally mediated elements of resistance that are considered essential are frequently underestimated.
Wedad M. Nageeb, Nada AlHarbi, Amani A. Alrehaili, Shadi A. Zakai, Ahmed Elfadadny, Helal F. Hetta   +5 more
doaj   +1 more source