Results 71 to 80 of about 462,631 (250)

Biofilm Formation and the Role of Efflux Pumps in ESKAPE Pathogens

Microorganisms
Nosocomial infections caused by ESKAPE pathogens represent a significant burden to global health. These pathogens may exhibit multidrug resistance (MDR) mechanisms, of which mechanisms such as efflux pumps and biofilm formation are gaining significant ...
Trent R. Sorenson, Kira M. Zack, Suresh G. Joshi   +2 more
doaj   +1 more source

Exploring the Contribution of the AcrB Homolog MdtF to Drug Resistance and Dye Efflux in a Multidrug Resistant E. coli Isolate

Antibiotics, 2021
In Escherichia coli, the role of RND-type drug transporters other than the major efflux pump AcrB has largely remained undeciphered (particularly in multidrug resistant pathogens), because genetic engineering in such isolates is challenging.
Sabine Schuster, Martina Vavra, Ludwig Greim, Winfried V. Kern   +3 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Structural basis for the blockade of MATE multidrug efflux pumps [PDF]

Nature Communications, 2015
AbstractMultidrug and toxic compound extrusion (MATE) transporters underpin multidrug resistance by using the H+ or Na+ electrochemical gradient to extrude different drugs across cell membranes. MATE transporters can be further parsed into the DinF, NorM and eukaryotic subfamilies based on their amino-acid sequence similarity.
Radchenko, Martha, Symersky, Jindrich, Nie, Rongxin, Lu, Min   +3 more
openaire   +2 more sources

Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition

Antibiotics, 2021
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major health threat worldwide due to significant morbidity and mortality resulting from their associated hospital- or community-acquired infections. Dramatic decrease in
Abolfazl Dashtbani-Roozbehani, Melissa H. Brown   +1 more
doaj   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Selecting surfactants for the maximum inhibition of the activity of the multidrug resistance efflux pump transporter, P-glycoprotein: conceptual development [PDF]

, 2016
Amphiphilic excipients, such as surfactants, have been shown to be inhibitors of the multidrug resistance (MDR) efflux pump transporter protein, P glycoprotein (Pgp).
Shireesh Apte
core  

Roles of Salmonella multidrug efflux pumps in tigecycline resistance [PDF]

Journal of Antimicrobial Chemotherapy, 2010
salmonella enterica strains exhibiting decreased susceptibility to tigecycline have been reported. In this study, we sought to elucidate the roles of Salmonella multidrug efflux pumps and AcrAB regulators in tigecycline resistance.we examined the involvement of multidrug efflux pumps and AcrAB regulators in resistance to tigecycline and other ...
Tsukasa, Horiyama, Eiji, Nikaido, Akihito, Yamaguchi, Kunihiko, Nishino   +3 more
openaire   +2 more sources

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Selecting surfactants for the maximum inhibition of the activity of the multidrug resistance efflux pump transporter, P-glycoprotein: conceptual development [PDF]

, 2010
Amphiphilic excipients, such as surfactants, have been shown to be inhibitors of the multidrug resistance (MDR) efflux pump transporter protein, P glycoprotein (Pgp).
Shireesh Apte
core