Results 41 to 50 of about 262,601 (237)
mBio, 2016 Multidrug efflux pumps provide clinically significant levels of drug resistance in a number of Gram-negative hospital-acquired pathogens. These pathogens frequently carry dozens of genes encoding putative multidrug efflux pumps.
Karl A. Hassan +13 more
doaj +1 more source
, 2022 Archive of efflux-pumps inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875) +5 more
core +1 more source
Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria
Antibiotics, 2015 Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria. Understanding the distribution, expression, and physiological functions of multidrug efflux pumps, especially under physiologically and clinically ...
Zeling Xu, Aixin Yan
doaj +1 more source
Clinical Status of Efflux Resistance Mechanisms in Gram-Negative Bacteria
Antibiotics, 2021 Antibiotic efflux is a mechanism that is well-documented in the phenotype of multidrug resistance in bacteria. Efflux is considered as an early facilitating mechanism in the bacterial adaptation face to the concentration of antibiotics at the infectious ...
Anne Davin-Regli +2 more
doaj +1 more source
Identification of a multidrug efflux pump inMycobacterium smegmatis [PDF]
FEMS Microbiology Letters, 2016 Cell wall impermeability and active efflux of drugs are among the primary reasons for drug resistance in mycobacteria. Efflux pumps are tripartite membrane localized transport proteins that expel drug molecules outside the cells. Several of such efflux pumps are annotated in mycobacteria, but few have been characterized, like MSMEG_2991, a putative ...
Ankita, Bansal +3 more
openaire +2 more sources
Nature Communications, 2018 Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer cells.
Hai Wang +12 more
doaj +1 more source
mBio, 2015 Multidrug efflux systems are a major cause of resistance to antimicrobials in bacteria, including those pathogenic to humans, animals, and plants. These proteins are ubiquitous in these pathogens, and five families of bacterial multidrug efflux systems ...
Karl A. Hassan +3 more
doaj +1 more source
Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii [PDF]
Journal of Antimicrobial Chemotherapy, 2007 Acinetobacter baumannii is an opportunistic pathogen, causing infections mainly in patients in intensive care units where the extensive use of antimicrobial agents can select for the emergence of multiresistant strains. In fact, since strains resistant to all antimicrobial agents have been reported, A.
Vila, Jordi +2 more
openaire +3 more sources
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui +9 more
wiley +2 more sources