Results 11 to 20 of about 262,601 (237)
RND multidrug efflux-pumps: what are they good for? [PDF]
Frontiers in Microbiology, 2013 Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics.
Carolina eAlvarez-Ortega +2 more
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Microbial Primer: Multidrug efflux pumps. [PDF]
Microbiology (Reading), 2023 Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell.
Siasat PA, Blair JMA.
europepmc +4 more sources
Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii, 2022 Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The
Sreekantan Abhirami P. +3 more
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Physiological Functions of Bacterial “Multidrug” Efflux Pumps [PDF]
Chemical Reviews, 2021 Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used to overcome their infections.
Henderson, P.J.F. +11 more
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Multidrug efflux pumps in Staphylococcus aureus: an update. [PDF]
The Open Microbiology Journal, 2013 The emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pumps, proteins ...
Couto, Isabel Maria dos Santos Leitão +3 more
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Antibiotics, 2023 Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections.
Asiyeh Avakh +4 more
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Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time
Antibiotics, 2021 The rise in multidrug resistance (MDR) is one of the greatest threats to human health worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial infections are becoming untreatable by commercially available antibiotics. One of
Martijn Zwama, Kunihiko Nishino
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A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus [PDF]
Journal of Antimicrobial Chemotherapy, 2003 GG918, a synthetic inhibitor of P-glycoprotein-mediated mammalian tumour multidrug resistance, was found to be equipotent to reserpine in enhancing the in vitro activity of norfloxacin and ciprofloxacin against strains of Staphylococcus aureus expressing
Kaatz, Glenn W. +2 more
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Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps. [PDF]
Curr Med Chem, 2016 Antimicrobial resistance represents a significant challenge to future healthcare provision. An acronym ESKAPEE has been derived from the names of the organisms recognised as the major threats although there are a number of other organisms, notably ...
Mahmood HY +3 more
europepmc +6 more sources
Multifunctional Bacterial Multi-Drug Efflux Pumps – not just for resistance
Nature Reviews Microbiology, 2006 It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s).
Piddock, Laura, Laura J. V. Piddock
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