Results 171 to 180 of about 208,103 (288)

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Chloramphenicol stress triggers oxidative adaptation in <i>Acinetobacter baumannii</i> ATCC19606 devoid of RND efflux pumps AdeAB or AdeIJ. [PDF]

mSystems
Foong WE, Xiang X, He W, Yan X, Huang J, Pos KM, Tam H-K.   +6 more
europepmc   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

From drug export to envelope fitness: characterizing the regulatory landscape of selective <i>Escherichia coli</i> ABC efflux pumps. [PDF]

Front Microbiol
Feng Z, Wu M, Yang C, Zheng W, Wang Y, Wang S, Liu D.   +6 more
europepmc   +1 more source

Electronic‐State Programming of Ultrasmall CeO2 Switches H2O2 Activation From Radical to Bio‐Inspired Nonradical 1O2 Generation for Combating Antibiotic Resistance

Advanced Science, EarlyView.
A scalable synthesis of carbon‐supported ultrasmall CeO2 nanoparticles with precisely tunable Ce electron density is reported. Electron‐lean Ce sites activate H2O2 exclusively via a nonradical pathway, enabling efficient HOBr and 1O2 production analogous to bromoperoxidase for contaminant and antibiotic resistance removal.
Bo Yuan, Xinyu Wu, Yin‐Song Liao, Chao Zhao, Zhanping Xiao, Wanqing Dai, Jyh‐Pin Chou, Wenchao Peng, Jian Lin Chen, Pi‐Tai Chou, Yung‐Kang Peng   +10 more
wiley   +1 more source

Computational and experimental evaluation of Pisolithus arhizus metabolites targeting major efflux pumps of mastitis-associated Staphylococcus aureus. [PDF]

PLoS One
Gul H, Zahra I, Nasreen Z, Khan HA, Naeem-Ul-Hassan M, Ahmad N, Assad N, Kifle D, Garrido-Palazuelos L.   +8 more
europepmc   +1 more source

A Compact Hollow Fiber Electrode Assembly Architecture for Continuous Electrochemical Marine Carbon Dioxide Removal

Advanced Energy Materials, EarlyView.
A coaxial, membrane‐integrated hollow fiber electrode assembly (HFEA) is developed for continuous marine carbon mineralization. By utilizing a sub‐millimeter inter‐electrode gap, the HFEA minimizes Ohmic losses, achieving 50% energy reduction and over 85% DIC removal.
Inhwan Park, Young Hun Lee, Jung Hun Lee, Seung‐Jeong Oh, T. Alan Hatton, Dong‐Yeun Koh   +5 more
wiley   +1 more source

Molecular mechanism of transition-state inhibitors of bacterial antibiotic efflux pumps. [PDF]

NPJ Antimicrob Resist
Börnsen C, Müller RT, Vieira Da Cruz A, Jiménez-Castellanos JC, Meurillon V, Brandstätter L, Lodinsky EV, Athar M, Vargiu AV, Hartkoorn RC, Flipo M, Frangakis AS, Pos KM.   +12 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source