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New-generation efflux pump inhibitors
Expert Review of Clinical Pharmacology, 2008The development of novel efflux pump inhibitors is an emerging and challenging research field. Besides the use of such excipients in cancer therapy, efflux pump inhibitors are gaining increasing interest with regards to drug delivery. In particular, inhibition of efflux pumps located in the intestine and the blood-brain barrier offers promising ...
Martin, Werle +2 more
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Efflux pump activity in Enchytraeidae
2019Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka +3 more
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Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour +3 more
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In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour +3 more
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Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps
2014Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
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Cholestasis and the Role of Basolateral Efflux Pumps
Zeitschrift für Gastroenterologie, 2011ATP-dependent transport of biliary constituents, such as bile acids, reduced glutathione, and bilirubin glucuronosides across the hepatocyte canalicular membrane into bile represents the decisive driving force for the formation of biliary fluid. Functional characterization, cloning, and localization of hepatocellular transporter proteins has provided a
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Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
2022Pallavi Ahirrao +2 more
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