Results 11 to 20 of about 90,161 (342)
Effects of efflux pumps on antifungal activity of chitosan against Candida albicans [PDF]
Journal of Oral MicrobiologyBackground Antifungal resistance is a major problem, commonly caused by drug-efflux pump overexpression. To evaluate if chitosan could be effective in drug-resistant Candida infections, we investigated the effects of efflux pumps on antifungal activity ...
Sureeporn Muangsawat +5 more
doaj +2 more sources
Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential [PDF]
mBioEfflux pumps are well known to be an important mechanism for removing noxious substances such as antibiotics from bacteria. Given that many antibiotics function by accumulating inside bacteria, efflux pumps contribute to resistance.
Emily E. Whittle +6 more
doaj +2 more sources
Identification and characterisation of two functional antibiotic MATE efflux pumps in the archaeon Halorubrum amylolyticum [PDF]
npj Antimicrobials and ResistanceMultidrug efflux pumps have been found to play a crucial role in drug resistance in bacteria and eukaryotes. In this study, we investigated the presence of functional multidrug and toxic compound extrusion (MATE) efflux pumps, inferred from whole genome ...
Asma A. Fakhoury +7 more
doaj +2 more sources
Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus. [PDF]
J Antimicrob ChemotherToepfer S +7 more
europepmc +2 more sources
Microbial Primer: Multidrug efflux pumps. [PDF]
Microbiology (Reading), 2023 Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial ...
Siasat PA, Blair JMA.
europepmc +4 more sources
Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino +4 more
doaj +1 more source
Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii - Advancements of Microbiology, 2022 Abstract Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs).
Sreekantan Abhirami P. +3 more
openaire +2 more sources
Susceptibility Tests and Predictions of Transporter Profile in Serratia Species
Microorganisms, 2022 Disinfectants and biosecurity are critically important to control microbial diseases. Resistance to disinfectants compromises sectors such as agriculture and healthcare systems.
Gunther J. Staats +3 more
doaj +1 more source
PLoS Biology, 2022 Bacteria have membrane-spanning efflux pumps to secrete toxic compounds ranging from heavy metal ions to organic chemicals, including antibiotic drugs.
Christopher J Stubenrauch +3 more
doaj +1 more source
Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]
, 2020 The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
core +2 more sources