Results 261 to 270 of about 85,671 (296)

Multidrug Efflux Pumps in the Genus Erwinia: Physiology and Regulation of Efflux Pump Gene Expression

2016
Plant pathogens belonging to the genus Erwinia cause diseases in several economically important plants. Plants respond to bacterial infection with a powerful chemical arsenal and signaling molecules to rid themselves of the microbes. Although our understanding of how Erwinia initiate infections in plants has become clear, a comprehensive understanding ...
J, Thekkiniath, R, Ravirala, M, San Francisco   +2 more
openaire   +2 more sources

Inhibitors of Efflux Pumps

Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar, Sudeshna Bhattacharjee, Rama Tyagi   +2 more
openaire   +1 more source

Antimicrobial Drug Efflux Pump Inhibitors

2016
Bacterial multidrug resistance is on the rise, and bacterial efflux pumps make a major contributor to this development. Efflux pump inhibitors (EPIs) may be a solution to this problem, since they can reverse resistance to clinically administered antimicrobial agents. Multiple EPIs with activity against Gram-positive and Gram-negative bacteria have been
Jürgen A. Bohnert, Winfried V. Kern
openaire   +1 more source

Efflux Pumps in Drug Resistance of Candida

Infectious Disorders - Drug Targets, 2006
The incidences of human pathogenic yeast Candida albicans and its related species acquiring resistance to antifungals have increased considerably, which poses serious problems towards its successful chemotherapy. The resistance of these pathogenic fungi is not restricted to the commonly used triazole compounds but is even encountered, though not often,
R, Prasad, N A, Gaur, M, Gaur, S S, Komath   +3 more
openaire   +2 more sources

Small Multidrug Resistance Efflux Pumps

2016
Small multidrug resistance (SMR) transporters confer resistance to a variety of quaternary cation compound antimicrobials. These secondary active transporters are the smallest known transporters and have been demonstrated to function within the membrane.
Denice C. Bay, Raymond J. Turner
openaire   +1 more source

Efflux pump activity in Enchytraeidae

2019
Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka, Lončarić, Željka, Hackenberger Kutuzović, Branimir, Kovačević, Marija   +3 more
openaire   +1 more source

Bacterial efflux pump inhibition.

Current opinion in investigational drugs (London, England : 2000), 2005
Drug efflux is recognized as a clinically relevant mechanism of antimicrobial drug resistance in selected species of bacteria. Membrane-based polypeptides belong to distinct protein superfamilies, the members of which are related by structural characteristics, mechanism of action and energy source for the transport process.
openaire   +1 more source

Strategies to Overcome Efflux Pumps

2009
Intestinal efflux pumps such as P-glycoprotein play a significant role in altering the absorption of a wide range of drugs. Anticancer agents, antibiotics, antivirals, calcium channel blockers, immunosuppressive agents, peptide drugs and several other therapeutic compounds have been reported to be substrates of one or more transmembrane efflux ...
openaire   +1 more source

Antibiotic resistance and efflux pumps

2019
The main purpose of this manuscript is to review the resistance against antibiotics and efflux pumps, one of the mechanisms important in resistance against antibiotics. As a definition, the resistance against antibiotics is accepted as the capability of a microorganism to resist the activity of antimicrobials, which were successfully used to kill the ...
ALTINÖZ, Eda, ALTUNER, Ergin Murat
openaire   +1 more source

Physiological Functions of Bacterial “Multidrug” Efflux Pumps

Chemical Reviews, 2021
Peter J F Henderson, Claire Maher, Liam D H Elbourne   +2 more
exaly