Results 31 to 40 of about 90,161 (342)
Efflux Pump Inhibitors against Nontuberculous Mycobacteria [PDF]
International Journal of Molecular Sciences, 2020 Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment of mycobacterial infections ...
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Introduction: Transporters, Porins, and Efflux Pumps [PDF]
Chemical Reviews, 2021 All living cells are surrounded by lipidic membranes that separate metabolic and macromolecular biosynthetic processes from external environments. Biological membranes vary dramatically in their composition and structures and are optimized by mega-annum of evolution to effectively carry out diverse biological functions including energy production ...
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Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Lulu Huang +8 more
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Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of Pseudomonas aeruginosa in a Galleria mellonella in vivo infection model [PDF]
, 2015 This work was supported by the University of St Andrews.Objectives: The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these ...
Adamson, Dougal +2 more
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Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]
International Journal of Molecular Sciences, 2012 Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
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Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumannii
New Microbes and New Infections, 2019 Acinetobacter baumannii is an important human pathogen responsible for a various type of infections. These bacterial strains are generally resistant to numerous antibiotics.
S.H. Ardehali +5 more
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Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]
, 2007 Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad +9 more
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Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
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Efflux pumps and microbial biofilm formation
Infection, Genetics and Evolution, 2023 Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Mahdyeh Neghabi, Hajiagha +1 more
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The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance
Antibiotics, 2020 Antibiotic resistance is on the rise and has become one of the biggest public health challenges of our time. Bacteria are able to adapt to the selective pressure exerted by antibiotics in numerous ways, including the (over)expression of efflux pumps ...
Anna Elisabeth Ebbensgaard +2 more
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