Results 101 to 110 of about 208,103 (288)

ABCABC Stacking‐Enabled Non‐Centrosymmetry 3R‐ZnIn2S4 Nanosheets for Piezocatalytic Uranium Extraction

Advanced Science, EarlyView.
The ABCABC stacking sequence in 2D ZnIn2S4 nanosheets creates intrinsic non‐centrosymmetry, enabling robust piezocatalysis under weak mechanical agitation. The nanosheets achieve a H2O2 yield of 276.7 µmol g−1 h−1 and uranium extraction capacity of 763.2 mg g−1 via a dual mechanism of direct piezoreduction and in situ H2O2 complexation.
Song Li, Huaijuan Zhou, Yingting Yang, Yanhong Lv, Zdeněk Sofer, Jianyun Zheng, Jinhua Li   +6 more
wiley   +1 more source

Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in Acinetobacter baumannii

, 2018
Yanpeng Zhang,1,2 Zhuocheng Li,2 Xiaolong He,1 Fanglin Ding,2 Weiqing Wu,2 Yong Luo,2 Bing Fan,2 Hong Cao1 1Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University,
Ding F, Li Z, Cao H, Zhang Y, He X, Luo Y, Wu W, Fan B   +7 more
core  

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii

, 2018
Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the ...
Jon W. Weeks, Inga V. Leus, Helen I. Zgurskaya, Vincent Bonifay, Lauren Smith, Sophie Richardson   +5 more
core   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Mycobacterium tuberculosis efflux pumps: an update

, 2013
The selection and diffusion of Mycobacterium tuberculosis multidrug-resistant (MDR-TB), extensively drug-resistant (XDR-TB) and, more recently, totally drug-resistant (TDR) strains constitute a serious threat for tuberculosis global control. Mycobacteria,
PASCA, MARIA ROSALIA, BURONI, SILVIA, RICCARDI, GIOVANNA   +2 more
core  

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Synthetic feedback loop model for increasing microbial biofuel production using a biosensor

Frontiers in Microbiology, 2012
Current biofuel production methods use engineered bacteria to break down cellulose and convert it to biofuel. A major challenge in microbial fuel production is that increasing biofuel yields can be limited by the toxicity of the biofuel to the organism ...
Mary eHarrison, Mary eDunlop
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Restoration of Antibiotic Effectiveness with P. hartigii Extract Against Multidrug-Resistant E. coli 

Medical Sciences Forum
Antibiotic resistance poses a critical threat to global health, largely driven by bacterial efflux pumps that expel antibiotics and reduce their efficacy.
Eda Altınöz, Ilgaz Akata, Ergin Murat Altuner   +2 more
doaj   +1 more source

MOLECULAR AND PHENOTYPIC CHARACTERIZATION OF EFFLUX PUMPS AND EFFLUX PUMPS INHIBITOR ON ANTIBIOTIC RESISTANCE OF SALMONELLA TYPHI IN BAGHDAD [PDF]

The aim of the study was investigate the occurrence of multidrug resistance efflux pumps genes in local clinical isolates of Salmonella sp and try to apply efflux inhibitor for phenotypic detection besides their possibly future therapeutic uses to retain
Nuha Joseph Kandala, Mustafa Faris Husain   +1 more
core   +1 more source