Results 121 to 130 of about 50,314 (155)

Inhibitors of Efflux Pumps

Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar, Sudeshna Bhattacharjee, Rama Tyagi   +2 more
openaire   +1 more source

New-generation efflux pump inhibitors

Expert Review of Clinical Pharmacology, 2008
The development of novel efflux pump inhibitors is an emerging and challenging research field. Besides the use of such excipients in cancer therapy, efflux pump inhibitors are gaining increasing interest with regards to drug delivery. In particular, inhibition of efflux pumps located in the intestine and the blood-brain barrier offers promising ...
Martin, Werle, Hirofumi, Takeuchi, Andreas, Bernkop-Schnürch   +2 more
openaire   +2 more sources

Efflux pump activity in Enchytraeidae

2019
Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka, Lončarić, Željka, Hackenberger Kutuzović, Branimir, Kovačević, Marija   +3 more
openaire   +1 more source

Determination of the Efflux Pump-Mediated Resistance Prevalence in Pseudomonas aeruginosa, Using an Efflux Pump Inhibitor

Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour, Shahin, Najar Peerayeh, Jalil F, Mehrabadi, Hadi, Rezaei Yazdi   +3 more
openaire   +2 more sources

Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps

2014
Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
openaire   +1 more source

Cholestasis and the Role of Basolateral Efflux Pumps

Zeitschrift für Gastroenterologie, 2011
ATP-dependent transport of biliary constituents, such as bile acids, reduced glutathione, and bilirubin glucuronosides across the hepatocyte canalicular membrane into bile represents the decisive driving force for the formation of biliary fluid. Functional characterization, cloning, and localization of hepatocellular transporter proteins has provided a
openaire   +2 more sources

Efflux pumps in multidrug-resistant Acinetobacter baumannii: Current status and challenges in the discovery of efflux pumps inhibitors

Microbial Pathogenesis, 2021
Monalisa Tiwari, Vishvanath Tiwari
exaly  

Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance

Trends in Microbiology, 2022
Mark Laws, Khondaker Miraz Rahman, Peiqin Jin   +2 more
exaly  

Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps

Antibiotics, 2023
Agata Fama, Concetta Beninati, Giuseppe Valerio de Gaetano   +2 more
exaly  

Efflux Pumps

RCSB Protein Data Bank
Steven Arnold, Shuchismita Dutta
openaire   +1 more source