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Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants [PDF]
Microorganisms, 2016 Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels.
Alejandra Bernardini +2 more
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Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Martijn Zwama +2 more
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Microbial Primer: Multidrug efflux pumps [PDF]
Microbiology, 2023 Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial ...
Pauline Ann Siasat, Jessica M. A. Blair
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Multidrug Efflux Pumps at the Crossroad Between Antibiotic Resistance and Bacterial Virulence
Frontiers in Microbiology, 2016 Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance.
Sara Hernando-Amado +2 more
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The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy [PDF]
Antibiotics, 2023 Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections.
Asiyeh Avakh +4 more
doaj +2 more sources
Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Xu Wang, Menghong Dai, Haihong Hao
exaly +3 more sources
Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps
Heliyon, 2023 S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the ...
Amandine Chauviat +2 more
doaj +2 more sources
Efflux pumps: gatekeepers of antibiotic resistance in Staphylococcus aureus biofilms
Microbial CellStaphylococcus aureus, a versatile human pathogen, poses a significant challenge in healthcare settings due to its ability to develop antibiotic resistance and form robust biofilms.
Shweta Sinha +2 more
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Efflux Pumps as Potential Targets for Biofilm Inhibition
Frontiers in MicrobiologyBiofilms account for a great deal of infectious diseases and contribute significantly to antimicrobial resistance. Efflux pumps confer antimicrobial resistance to microorganisms and involve multiple processes of biofilm formation. Efflux pump inhibitors (
Zhonghao Liu
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Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]
International Journal of Molecular Sciences, 2012 Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
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