Results 41 to 50 of about 170,445 (249)
The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance
Antibiotics, 2020 Antibiotic resistance is on the rise and has become one of the biggest public health challenges of our time. Bacteria are able to adapt to the selective pressure exerted by antibiotics in numerous ways, including the (over)expression of efflux pumps ...
Anna Elisabeth Ebbensgaard +2 more
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Frontiers in Microbiology, 2015 The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable.
Karl A Hassan +9 more
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Detection of tetracyclines and efflux pump inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1993 Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein +6 more
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Roles of SmeYZ, SbiAB, and SmeDEF Efflux Systems in Iron Homeostasis of Stenotrophomonas maltophilia
Microbiology Spectrum, 2022 Stenotrophomonas maltophilia, a nonfermenting Gram-negative rod, is frequently isolated from the environment and is emerging as a multidrug-resistant global opportunistic pathogen. S.
Chao-Jung Wu +6 more
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Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
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Role of bacterial efflux pumps in biofilm formation [PDF]
, 2018 Efflux pumps are widely implicated in antibiotic resistance because they can extrude the majority of clinically relevant antibiotics from within cells to the extracellular environment.
Rahman, Khondaker Miraz +8 more
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Efflux Pumps and These Inhibitors
VNU Journal of Science: Medical and Pharmaceutical Sciences, 2019 In this era of multi-drug resistance, efflux pump is one of the major problems which is increasingly concerned by scientists. The structure and mechanism activity of the efflux pumps on both bacteria and eurakyotes that are gradually being clarified. Since then, efflux pump inhibitors have also been studied and initially applied in clinic, that makes ...
Le Minh Tri +6 more
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Development of Nucleic Acid Aptamers to Inhibit Bacterial Efflux Pumps [PDF]
, 2021 Multidrug resistance in bacteria, defined as the ability of a bacterial strain to resist the killing effects of more than one antibiotic, represents a major threat to global healthcare.
Moses, Emilie A.
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Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. [PDF]
PLoS ONE, 2012 The resistance-nodulation-division (RND) efflux systems are ubiquitous transporters that function in antimicrobial resistance. Recent studies showed that RND systems were required for virulence factor production in Vibrio cholerae. The V. cholerae genome
Dawn L Taylor +2 more
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Investigating the Escherichia coli Drug Efflux System: Generation of an Efflux Deficient Genetic Background [PDF]
, 2021 The Escherichia coli drug efflux network is expansive and complex, encompassing 37 efflux pump encoding genes. Several efflux pumps, such as the AcrAB-TolC complex, display promiscuous substrate specificities, which contributes significantly to ...
Teelucksingh, Tanisha
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