Results 91 to 100 of about 3,601 (193)
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules:Synthesis, electrochemical and SAR study [PDF]
, 2018 International audienceTo study the antiparasitic 8-nitroquinolin-2(1H)-one pharmacophore, a series of 31 derivatives was synthesized in 1-5 steps and evaluated in vitro against both Leishmania infantum and Trypanosoma brucei brucei.
Azas, Nadine +18 more
core +4 more sources
Detection of group 1 Trypanosoma brucei gambiense by loop-mediated isothermal amplification [PDF]
, 2011 Trypanosoma brucei gambiense group 1 is the major causative agent of the Gambian human African trypanosomiasis (HAT). Accurate diagnosis of Gambian HAT is still challenged by lack of precise diagnostic methods, low and fluctuating parasitemia, and ...
Njiru, Z. K. +4 more
core +1 more source
Frontiers in Aging Neuroscience, 2018 Background: Recent genome-wide association screening (GWAS) studies have linked Alzheimer's disease (AD) neuropathology to gene networks that regulate immune function. Kan et al.
Jessica Alber +6 more
doaj +1 more source
Eflornithine Is Safer than Melarsoprol for the Treatment of Second-Stage Trypanosoma brucei gambiense Human African Trypanosomiasis [PDF]
, 2017 Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
Bovier, Patrick A. +4 more
core
Evaluating 5-nitrothiazoles as trypanocidal agents [PDF]
, 2015 OA Monitor ExerciseOA Monitor ExerciseThe growth inhibitory properties of a 5-nitrothiazole series was evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency towards the parasite while exhibiting little ...
Aguilera-Venegas, B +3 more
core +1 more source
Kinetoplastida: new therapeutic strategies
Parasite, 2008 New formulations and therapeutic switching of the established drugs, amphotericin B and paromomycin, together with the discovery of miltefosine, have significantly improved the opportunities for treatment of visceral leishmaniasis (VL) chemotherapy ...
Croft S.L.
doaj +1 more source
Targeting Pharmacological and Nanotechnology Based Therapeutics for Management of Hirsutism: A Comprehensive State-of-the-Art [PDF]
Pharmaceutical SciencesHirsutism is characterized by the excessive growth of coarse hair in women, resembling the typical pattern seen in men. It affects between 5 to 10 % of females of reproductive age.
Ishrat Zahoor +4 more
doaj +1 more source
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis [PDF]
, 2017 Despite the fact that eflornithine was considered as the safer drug to treat human African trypanosomiasis (HAT) and has been freely available since 2001, the difficulties in logistics and cost burden associated with this drug meant that the toxic ...
DIARRA, A. +4 more
core
Clinical Endocrinology, Volume 101, Issue 5, Page 562-568, November 2024.
Adrian H. Heald +4 more
wiley +1 more source