Results 131 to 140 of about 1,824 (166)
'Mitotic' kinesin-5 is a dynamic brake for axonal growth in Drosophila.
DevelopmentLu W +5 more
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Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20. [PDF]
Br J CancerFatima I +8 more
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NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression. [PDF]
J Cell BiolSun M +5 more
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Prognostic value of fatty acid metabolism-related signature and integrated analysis of the immune microenvironment in multiple myeloma. [PDF]
BMC CancerYu Y, Che F.
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Roles of post-translational modifications of UHRF1 in cancer. [PDF]
Epigenetics ChromatinGu L, Fu Y, Li X.
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The Discovery and Development of Eg5 Inhibitors for the Clinic
, 2015 The mitotic kinesin Eg5 (also known as kinesin spindle protein, KSP, Kif11, a member of the kinesin-5 family) represents an attractive oncology drug target in the ongoing development of anti-mitotic drugs that selectively block mitosis through disruption to the mitotic spindle. In this state-of-the-art review, we outline the progress that has been made
Good, James A. D. +3 more
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Synthesis and Biological Evaluation of Novel Eg5 Inhibitors
ChemBioChem, 2005AbstractHuman Eg5 is a mitotic kinesin that is essential for bipolar spindle formation and maintenance during mitosis. Recently, the discovery of compounds that inhibit Eg5 and cause mitotic arrest has attracted great interest, due to their potential use as the next generation of antimitotics. Here, we present the synthesis and biological investigation
Vasiliki Sarli, Thomas U Mayer
exaly +4 more sources