Results 31 to 40 of about 1,824 (166)
The kinesin-12 Kif15 is a processive track-switching tetramer [PDF]
, 2014 Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
McHugh, Toni +9 more
core +1 more source
Morelloflavone as a novel inhibitor of mitotic kinesin Eg5
The Journal of Biochemistry, 2019 AbstractAmong 40 plant-derived biflavonoids with inhibitory potential against Eg5, morelloflavone from Garcinia dulcis leaves was selected for further testing based on in silico analysis of binding modes, molecular interactions, binding energies and functional groups that interact with Eg5.
Tomisin Happy Ogunwa +5 more
openaire +2 more sources
Cell Reports, 2015 Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal resistance.
Shrikanta Chattopadhyay +32 more
doaj +1 more source
Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. [PDF]
PLoS ONE, 2012 Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we
Line Groth-Pedersen +5 more
doaj +1 more source
An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. [PDF]
PLoS ONE, 2009 Kinesin-5 (also known as Eg5, KSP and Kif11) is required for assembly of a bipolar mitotic spindle. Small molecule inhibitors of Kinesin-5, developed as potential anti-cancer drugs, arrest cell in mitosis and promote apoptosis of cancer cells.
Melody Tsui +7 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis. [PDF]
Mol OncolAurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Abdelkabir H +2 more
europepmc +2 more sources
Development of a Drosophila cell-based error correction assay
Frontiers in Oncology, 2013 Accurate transmission of the genome through cell division requires microtubules from opposing spindle poles to interact with protein super-structures called kinetochores that assemble on each sister chromatid.
Jeffrey D. Salemi +3 more
doaj +1 more source
HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation [PDF]
Cell Chemical Biology, 2017 Histone deacetylase 1 (HDAC1) is an epigenetic enzyme that regulates key cellular processes, such as cell proliferation, apoptosis, and cell survival, by deacetylating histone substrates. Aberrant expression of HDAC1 is implicated in multiple diseases, including cancer. As a consequence, HDAC inhibitors have emerged as effective anti-cancer drugs. HDAC
Dhanusha A, Nalawansha +3 more
openaire +2 more sources
Cell Reports, 2014 The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation.
Manuel Eguren +10 more
doaj +1 more source
Molecules, 2019 S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer activity owing to its potent inhibitory effect on human mitotic kinesin Eg5.
Mohamed O. Radwan +11 more
doaj +1 more source