Results 41 to 50 of about 1,824 (166)

New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy

, 2006
The treatment of malignant brain tumors poses a basic challenge in todays cancer therapy. Since the quantitative resection is hardly possible due to the invasive growth of the tumor, prevention of relapse after resection by concomitant irradiation ...
Gross, Dietmar
core   +1 more source

Monastrol derivatives: in silico and in vitro cytotoxicity assessments

Research in Pharmaceutical Sciences, 2020
Background and purpose: Cancer is the leading cause of death in today’s world, therefore the efforts to achieve anticancer drugs with higher potency and fewer side effects have always been conducted by researchers in the field of pharmaceutical chemistry.
Zahra Bidram, Hajar Sirous, Ghadam Ali Khodarahmi, Farshid Hassanzadeh, Nasim Dana, Amir Ali Hariri, Mahboubeh Rostami   +6 more
doaj   +1 more source

Image_1_Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC.tiff

, 2022
The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear.
Isabel Garcia-Saez (6999704), Dimitrios A. Skoufias (173868), Salvatore DeBonis (2449534), Rose-Laure Indorato (2449525)   +3 more
core   +1 more source

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination. [PDF]

Bioessays
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Sala C, Schiebel E.
europepmc   +2 more sources

Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance

, 2021
International audienceEg5, the product of Kif11 gene, also known as kinesin spindle protein, is a motor protein involved in the proper establishment of a bipolar mitotic spindle.
Skoufias, Dimitrios, A, Garcia-Saez, Isabel   +1 more
core   +1 more source

Image_3_Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC.tiff

, 2022
The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear.
Isabel Garcia-Saez (6999704), Dimitrios A. Skoufias (173868), Salvatore DeBonis (2449534), Rose-Laure Indorato (2449525)   +3 more
core   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Image_2_Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC.tiff

, 2022
The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear.
Isabel Garcia-Saez (6999704), Dimitrios A. Skoufias (173868), Salvatore DeBonis (2449534), Rose-Laure Indorato (2449525)   +3 more
core   +1 more source

Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle.

PLoS ONE, 2017
In infected cells rotavirus (RV) replicates in viroplasms, cytosolic structures that require a stabilized microtubule (MT) network for their assembly, maintenance of the structure and perinuclear localization.
Selene Glück, Antonino Buttafuoco, Anita F Meier, Francesca Arnoldi, Bernd Vogt, Elisabeth M Schraner, Mathias Ackermann, Catherine Eichwald   +7 more
doaj   +1 more source

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, Volume 83, Issue 6, Page 384-393, June 2026.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source