Results 81 to 90 of about 1,824 (166)

Cytotoxic monastrol derivatives as adjective inhibitors of drug-resistant Eg5: a molecular dynamics perspective

The mitotic kinesin Eg5 is a motor protein involved in the formation of bipolar spindle and cell division. Eg5 is overexpressed in various cancer cells and Eg5 targeting agents are promising candidates for cancer therapy.
N. Razzaghi-Asl (18119229), S. Shahabipour (18119223), A. N. Shamkhali (18119226)   +2 more
core   +1 more source

New chemical tools for investigating human mitotic kinesin Eg5

, 2007
We have designed and synthesized a series of monastrol derivatives, an allosteric inhibitor of Eg5, a motor protein responsible for the formation and maintenance of the bipolar spindle in mitotic cells.
DeBonis, S, Thiede, Bernd, Salvatore DeBonis, Klein, E, Emmanuel Klein, Debonis, Salvatore, Skoufias, DA, Luc Lebeau, Bernd Thiede, Lebeau, Luc, Frank Kozielski, Kozielski, F, Skoufias, Dimitrios, Kozielski, Frank, Dimitrios A. Skoufias, Lebeau, L, Thiede, B, Klein, Emmanuel   +17 more
core   +1 more source

The Quest for Ligands Against Kinesin Motor Protein Eg5

The Kinesin Eg5 motor protein is essential for the formation of the mitotic spindles and chromosome segregation, which is necessary for cell division. The inhibition of Eg5 has emerged as a potential therapeutic strategy for inhibiting the uncontrolled ...
Carradori S., Akdemir A., Ricci A., Rashad M., Sahin A. F.   +4 more
core   +1 more source

Inhibitory Mechanism of Photochromic Inhibitor for Mitotic Kinesin Eg5 [PDF]

Biophysical Journal, 2020
Kei Sadakane, Islam Md Alrazi, Kenichi Taii, Tomisin H. Ogunwa, Takayuki Miyanishi, Shinsaku Maruta   +5 more
openaire   +1 more source

Computational analysis of the interactions between the allosteric inhibitor fideloside and Eg5 kinesin

, 2023
Eg5 es una quinesina que desempeña un papel crucial en la formación y mantenimiento de la bipolaridad del huso mitótico. La inhibición de Eg5 puede resultar en arresto mitótico y muerte celular regulada.
Colina, Enrique, Sánchez Lamar, Ángel, Suárez, Jennifer, Alpízar, Daniel   +3 more
core  

A Novel Action of Terpendole E on the Motor Activity of Mitotic Kinesin Eg5

, 2003
To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E
Junichiro Yajima, Takatsuki, Akira, Hiroyuki Osada, Takeo Usui, Yajima, Junichiro, Akira Takatsuki, Usui, Takeo, Toyoshima, Yoko Y., Ueki, Masashi, Imoto, Masaya, Osada, Hiroyuki, Masaya Imoto, Masashi Ueki, Nakazawa, Junko, Junko Nakazawa, Yoko Y. Toyoshima   +15 more
core   +1 more source

Study on the highly efficient photoregulation of mitotic kinesin Eg5 using novel photo-chromic inhibitor

, 2018
創価大学博士（工学）Living cell is composed of millions of densely packed biomolecules that perform so many tasks to constitute life. Recently, the structure and function of the biomolecules that have a key role in cell motility have been clarified.
Sadakane, Kei, 貞包, 慧
core  

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation

, 2016
Inhibition of the microtubule (MT) motor protein Eg5 results in a mitotic arrest due to the formation of monopolar spindles, making Eg5 an attractive target for anti-cancer therapies. However, Eg5-independent pathways for bipolar spindle formation exist,
Halim, Vincentius A, Heck, Albert J R, van Heesbeen, Roy G H P, Marvin E. Tanenbaum, David A. Egan, Roy G. H. P. van Heesbeen, Tanenbaum, Marvin E, Sub Biomol.Mass Spectrometry & Proteom., Vincentius A. Halim, Lelieveld, Daphne, Biomolecular Mass Spectrometry and Proteomics, Raaijmakers, Jonne A, Medema, René H, René H. Medema, Jonne A. Raaijmakers, Cor Lieftink, Egan, David A, Albert J. R. Heck, Daphne Lelieveld, Lieftink, Cor, Afd Biomol.Mass Spect. and Proteomics   +20 more
core   +1 more source

Structure−Activity Relationship and Multidrug Resistance Study of New S-trityl-l-Cysteine Derivatives As Inhibitors of Eg5

, 2016
The mitotic spindle is a validated target for cancer chemotherapy. Drugs such as taxanes and vinca alkaloids specifically target microtubules and cause the mitotic spindle to collapse.
Katarzyna Tkocz (2218888), Dominik Menger (2218885), Venkatasubramanian Ulaganathan (1993690), Hung Yi Kristal Kaan (1293831), Johanna Weiss (294205), Frank Kozielski (1283658), Christian Laggner (487133), Florence Popowycz (2095825), Benoît Joseph (2218882)   +8 more
core   +1 more source

Structure−Activity Relationship and Multidrug Resistance Study of NewS-trityl-l-Cysteine Derivatives As Inhibitors of Eg5

, 2011
The mitotic spindle is a validated target for cancer chemotherapy. Drugs such as taxanes and vinca alkaloids specifically target microtubules and cause the mitotic spindle to collapse.
Venkatasubramanian Ulaganathan, Laggner, Christian, Florence Popowycz, Tkocz, K., Kaan, H.Y.K., Joseph, Benoît, Frank Kozielski, Menger, D., Hung Yi Kristal Kaan, Christian Laggner, Popowycz, Florence, Kaan, Hung Yi Kristal, Tkocz, Katarzyna, Weiss, J., Joseph, B., Dominik Menger, Ulaganathan, V., Johanna Weiss, Ulaganathan, Venkatasubramanian, Popowycz, F., Benoît Joseph, Katarzyna Tkocz, Kozielski, Frank, Kozielski, F., Menger, Dominik, Laggner, C., Weiss, Johanna   +26 more
core   +1 more source