Results 101 to 110 of about 1,824 (166)

Design, synthesis and pharmacological evaluation of new inhibitors of the kinesin Eg5

, 2014
Le cancer est un problème très présent dans nos sociétés modernes. En effet en 2010 il touchait plus de 10 millions de personnes dans le monde. Aujourd'hui cette maladie est la première cause de mortalité dans les pays industrialisés.Malheureusement, les
Leclercq, Julien
core  

E3 ubiquitin ligase RNF40: Structure, function and its context‑dependent roles in tumorigenesis (Review). [PDF]

Oncol Rep
Wu Z, Yang H, Chen G, Zhao W, Bao B, Luv C, Zhu W, Liu F, Ai H, Li Z.   +9 more
europepmc   +1 more source

Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays. [PDF]

Int J Mol Sci
Guo S, Zhang M, Zhang X, Yuan W, Zi C, Xiang Z, Xi Y.   +6 more
europepmc   +1 more source

Study of the interactions between the mitotic kinesin Eg5 and its inhibitors

, 2005
La kinésine mitotique humaine HsEg5 est essentielle à la division cellulaire. Ce moteur moléculaire permet la séparation des centrosomes et la mise en place du fuseau mitotique, structure nécessaire au partage équitable de l'information génétique.
openaire   +1 more source

Targeting Kinesins for Therapeutic Exploitation of Chromosomal Instability in Lung Cancer. [PDF]

Cancers (Basel)
Zhang C, Wu BZ, Thu KL.
europepmc   +1 more source

In-silico-based lead optimization of hit compounds targeting mitotic kinesin Eg5 for cancer management. [PDF]

In Silico Pharmacol
Bodun DS, Omoboyowa DA, Olofinlade VF, Ayodeji AO, Mauri A, Ogbodo UC, Balogun TA.   +6 more
europepmc   +1 more source

Lessons Learned from a Ligand-Unbinding Stress Test for Weighted Ensemble Simulations. [PDF]

ACS Omega
Bogetti AT, Yang DT, Piston HE, LeBard DN, Chong LT.   +4 more
europepmc   +1 more source

Multiple Regulatory Mechanisms of Post-Translational Modifications and Therapeutic Potential of Mitotic Catastrophe. [PDF]

Int J Mol Sci
Zhang QY, Chen X, Li SK, Cao LZ, Wang SY, He YJ, Zhang XL, Liu JW, Liu XF.   +8 more
europepmc   +1 more source

ATP-competitive inhibitors for cancer treatment - kinases and the world beyond. [PDF]

RSC Med Chem
Jug A, Ilaš J.
europepmc   +1 more source

Microtubule Association of EML4-ALK V3 Is Key for the Elongated Cell Morphology and Enhanced Migration Observed in V3 Cells. [PDF]

Cells
Papageorgiou S, Pashley SL, O'Regan L, Straatman KR, Fry AM.   +4 more
europepmc   +1 more source