Results 11 to 20 of about 741,060 (264)

KRAS mutation analysis by PCR : a comparison of two methods [PDF]

, 2015
Background: KRAS mutation assays are important companion diagnostic tests to guide anti-EGFR antibody treatment of metastatic colorectal cancer. Direct comparison of newer diagnostic methods with existing methods is an important part of validation of ...
Lucas, Katie, Anne Reiman, Reiman, Anne, Louise Bolton, Timms, Judith, Katie Lucas, Ian A Cree, Bolton, Louise, Cree, Ian A., Judith Timms   +9 more
core   +2 more sources

Case Report: Dacomitinib is effective in lung adenocarcinoma with rare EGFR mutation L747P and brain metastases

Frontiers in Oncology, 2022
Due to the low incidence of rare EGFR mutation, its response to EGFR-TKI has not been fully investigated. L747P is a rare EGFR mutation in EGFR exon 19.
Yibin Li, Weixi Guo, Bin Jiang, Chengkun Han, Feng Ye, Jingxun Wu   +5 more
doaj   +1 more source

Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line.

PLoS ONE, 2020
In non-small cell lung cancer (NSCLC), oncogenic driver mutations including those in KRAS and EGFR are typically mutually exclusive. However, recent reports indicate that multiple driver mutations are found in a certain percentage of cancers, and that ...
Yoshinori Tsukumo, Mikihiko Naito, Takayoshi Suzuki   +2 more
doaj   +1 more source

Somatic mutation subtypes of lung adenocarcinoma in East Asian reveal divergent biological characteristics and therapeutic vulnerabilities

iScience, 2021
Summary: Lung adenocarcinoma (LUAD) patients in East Asia predominantly harbor oncogenic EGFR mutations. However, there remains a limited understanding of the biological characteristics and therapeutic vulnerabilities of the concurrent mutations of EGFR ...
Wai-Kok Choong, Ting-Yi Sung
doaj   +1 more source

Detection and Evaluation of EGFR Mutation Status in Serum of Patients with Advanced Non-small Cell Lung Cancer Treated with EGFR-TKIs

Chinese Journal of Lung Cancer, 2013
Background and objective Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has shown a high response rate in the treatment of lung cancer in patients with (EGFR) mutation.
Ling MA, Li LIU, Tao ZHANG, Li SHAN
doaj   +1 more source

Mutation testing on an object-oriented framework: An experience report [PDF]

, 2011
This is the preprint version of the article - Copyright @ 2011 ElsevierContext The increasing presence of Object-Oriented (OO) programs in industrial systems is progressively drawing the attention of mutation researchers toward this paradigm.
Sergio Segura, Segura, S, Benavides, D, Antonio Ruiz-Cortés, Ruiz Cortés, Antonio, Segura Rueda, Sergio, Robert M. Hierons, Benavides Cuevas, David Felipe, Hierons, Robert M., David Benavides, Hierons, RM, Ruiz-Cortes, A   +11 more
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The Frequency of Epidermal Growth Factor Receptor Mutation of Nonsmall Cell Lung Cancer according to the Underlying Pulmonary Diseases

Pulmonary Medicine, 2011
Background. Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are effective in patients with nonsmall cell lung cancer with epidermal growth factor receptor (EGFR) mutation, EGFR-TKIs have a risk of inducing fatal ...
Kazuhiro Usui, Tomonori Ushijima, Yoshiaki Tanaka, Chiharu Tanai, Hiromichi Noda, Norifumi Abe, Hajime Horiuchi, Teruo Ishihara   +7 more
doaj   +1 more source

EGFR Mutation in Nasopharyngeal Carcinoma

, 2022
Nasopharyngeal carcinoma is a malignant tumor of the nasopharynx. However, while radiotherapy is the primary choice of treatment, the treatment may fail due to distant metastasis in most patients at an advanced stage.
Evren Uzun, Suna Erkilic
core   +1 more source

Detection of EGFR Mutations in Cerebrospinal Fluid of EGFR-Mutant Lung Adenocarcinoma With Brain Metastases

Frontiers in Oncology, 2021
BackgroundWe aimed to investigate the feasibility of detecting epidermal growth factor receptor (EGFR) mutations in cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) and plasma of advanced lung adenocarcinoma (LADC) with brain metastases (BMs) by ...
Liang Shi, Junfang Tang, Hong Tao, Lili Guo, Weihua Wu, Hongbo Wu, Zichen Liu, Li Tong, Wei Wu, Hongxia Li, Qiyi Meng, Liyan Xu, Nanying Che, Zhe Liu   +13 more
doaj   +1 more source

Comparison of Different EGFR Gene Mutation Status in Patients with Metastatic Non-Small Lung Cancer After First-Line EGFR-TKIs Therapy and Analyzing Its Relationship with Efficacy and Prognosis

Cancer Management and Research, 2021
Chengliang Yuan, Huiqin Jiang, Wei Jiang, Huilin Wang, Cuiyun Su, Shaozhang Zhou Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning City, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of ...
Yuan C, Jiang H, Jiang W, Wang H, Su C, Zhou S   +5 more
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