Results 21 to 30 of about 741,060 (264)

A rare epidermal growth factor receptor (EGFR) gene mutation in small cell lung carcinoma patients

Biomedical Papers, 2022
Aim. Activating mutations in the epidermal growth factor receptor (EGFR) are predominantly detected in pulmonary adenocarcinoma and have been reported in small cell lung cancer (SCLC) for decades. This retrospective single-center study aimed to determine
Cheng-Cheng Hwang, Tsan-Yu Hsieh, Kun-Yang Yeh, Tzu-Ping Chen, Chung-Ching Hua, Liang-Che Chang, Jim-Ray Chen   +6 more
doaj   +1 more source

Osimertinib – effective treatment of NSCLC with activating EGFR mutations after progression on EGFR tyrosine kinase inhibitors [PDF]

, 2017
Non-small cell lung cancer (NSCLC) driven by activating mutations in epidermal growth factor receptor (EGFR) constitutes up to 10% of NSCLC cases. According to the NCCN recommendations, all patients (with the exception of smoking patients with squamous ...
Marcin Skrzypski, Amelia Szymanowska-Narloch, Rafał Dziadziuszko   +2 more
core   +1 more source

Clinical performance evaluation of the Idylla™ EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cancer [PDF]

, 2020
BACKGROUND: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy with tyrosine kinase ...
Nadal, Ernest, Delgado García, Mercedes, Álava, Enrique de, Biscuola, Michele, Matias-Guiu, Xavier, 1958-, Delgado-Garcia, Mercedes, Gómez Izquierdo, Lourdes, Marquez-Lobo, Belgica, Gomez-Izquierdo, Lourdes, Varela, Mar, Matias-Guiu, Xavier, Weynand, Birgit, Alarcao, Ana, Jose Hernandez, Maria, Márquez Lobo, Bélgica, de Alava, Enrique, Varela Rodríguez, Mar, Hernández, María José, Blanco, Angela Maria   +18 more
core   +1 more source

Results of EGFR Mutations Detected in Pleural Effusion and Its 
Clinical Significance in 132 Patients with Advanced Non-small Cell Lung Cancer: 
A Retrospective Study in A Single Center

Chinese Journal of Lung Cancer, 2020
Background and objective The lack of pathological quality control standard in detecting epidermal growth factor receptor (EGFR) gene mutation in malignant pleural effusion leads to confusion in the interpretation of detection results and the clinical use
Tao LU, Qiang LI, Lan LI, Kaizhen YANG, Danfei ZHOU, Jie GAO, Minjiang CHEN, Yan XU, Wei ZHONG, Mengzhao WANG, Zhiyong LIANG, Jing ZHAO   +11 more
doaj   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A, Adriaens, M.E., Adriaens, Michiel E., Kolch, W, Amelie Gormand, Adriaens, ME, Gormand, A., Sturm, OE, David R Gilbert, Richard J Orton, Walter Kolch, Orton, RJ, Orton, Richard J., Oliver E Sturm, Gilbert, D, Gilbert, David R., Michiel Adriaens, M.E., Michiel E Adriaens, Orton, R.J., Kolch, Walter, Kolch, W., Gilbert, D.R., Sturm, O.E., Sturm, Oliver E., et al., Gormand, Amelie, Gormand, Amelie,, Lund University.   +27 more
core   +1 more source

Suitability of Surgical Tumor Tissues, Biopsy, or Cytology Samples for Epidermal Growth Factor Receptor Mutation Testing in Non–Small Cell Lung Carcinoma Based on Chinese Population

Translational Oncology, 2014
BACKGROUND: Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non–small cell lung cancer (NSCLC) patients; however, the detection materials’ availability remains challenging in clinical practice. In this study,
Xiaohong Han, Zhishang Zhang, Di Wu, Yinchen Shen, Shuai Wang, Lin Wang, Yutao Liu, Sheng Yang, Xingsheng Hu, Yun Feng, Yan Sun, Yuankai Shi   +11 more
doaj   +1 more source

Good Response to Gefitinib in Lung Adenocarcinoma of Complex Epidermal Growth Factor Receptor (Egfr) Mutations with the Classical Mutation Pattern

, 2011
Background. Epidermal growth factor receptor (EGFR) mutations are usually detected in lung adenocarcinoma and are associated with a response to EGFR tyrosine kinase inhibitors (TKIs).
WU, SHANG-GIN;CHANG, YIH-LEONG;WU, JENN-YU;YANG, CHIH-HSIN;YU, CHONG-JEN;TSAI, MENG-FENG;SHIH, JIN-YUAN;YANG, PAN-CHYR, 吳尚俊;張逸良;巫震宇;楊志新;余忠仁;蔡孟峰;施金元;楊泮池   +1 more
core   +1 more source

Pretreatment Lipoprotein(a) as a Biomarker for EGFR Mutation and Prognosis in Lung Adenocarcinoma. [PDF]

Int J Gen Med
Ji Liu,1 Zhekang Liu,2 Deming Xu,1 Tao Zhou,1 Ang Li,1 Jiali Hu,1 Hong Li,3 Wenjie Li,1 Zengqing Wang,1 Zhiping Yu,1 Linxiang Zeng1 1Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang ...
Liu J, Liu Z, Xu D, Zhou T, Li A, Hu J, Li H, Li W, Wang Z, Yu Z, Zeng L.   +10 more
europepmc   +2 more sources

Analyzing the Sensitivity of EGFR-L861Q Mutation to TKIs and A Case Report

Chinese Journal of Lung Cancer, 2015
Background and objective The significant efficacy of tyrosine kinase inhibitors (TKIs) has been approved for advanced non-small cell lung cancer (NSCLC) patients with activating epidermal growth factor receptor (EGFR) mutations.
Xingxing WANG, Yutong DONG, Tingting LIANG, Xiongji ZHANG, Kewei MA, Yongsheng CUI   +5 more
doaj   +1 more source

EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy.

PLoS ONE, 2013
Screening for EGFR mutation is a key molecular test for management of lung cancer patients. Outcome of patients with mutation receiving EGFR tyrosine kinase inhibitor is known to be better across different ethnic populations.
Vanita Noronha, Kumar Prabhash, Abhishek Thavamani, Anuradha Chougule, Nilendu Purandare, Amit Joshi, Rashmi Sharma, Saral Desai, Nirmala Jambekar, Amit Dutt, Rita Mulherkar   +10 more
doaj   +1 more source