Results 1 to 10 of about 111,781 (135)

Primary envelopment of Kaposi’s sarcoma-associated herpesvirus at the nucleoplasmic reticulum [PDF]

Journal of Virology
Herpesvirus egress begins with primary envelopment of newly assembled capsids at the inner nuclear membrane (INM). Primary envelopment has been observed at the peripheral INM as well as nuclear infoldings. Nuclear infoldings from invaginations of the INM
Alexa Wilson, Neale D. Ridgway, Craig McCormick   +2 more
doaj   +2 more sources

Evaluation on Egress Safety of Nursing Hospital Considering the Smoke Exhaust System

Fire, 2022
This study aimed to evaluate the egress safety in nursing hospitals based on the capacity of the smoke exhaust system. To this end, the available safe egress time was calculated by analyzing changes in visibility, carbon monoxide, carbon dioxide, oxygen ...
Seung-Ho Choi, Khaliunaa Darkhanbat, Inwook Heo, Kang Su Kim   +3 more
doaj   +1 more source

Unsteady Numerical Investigation on Vortex Interaction between Rim Seal Purge Flow and Upstream Stator [PDF]

Journal of Applied Fluid Mechanics, 2022
To assess unsteady vortex interaction between rim seal purge flow and upstream stator, numerical ‎investigations were conducted under different purge flow rates.
L. Zhou, Z. X. Wang, F. Yang, J. W. Shi
doaj   +1 more source

PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion

Frontiers in Cellular and Infection Microbiology, 2022
The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial ...
Claudia B. G. Barnes, Claudia B. G. Barnes, Madeline G. Dans, Madeline G. Dans, Thorey K. Jonsdottir, Thorey K. Jonsdottir, Brendan S. Crabb, Brendan S. Crabb, Brendan S. Crabb, Paul R. Gilson, Paul R. Gilson   +10 more
doaj   +1 more source

A system for efficient egress scheduling during mass events and small-scale experimental demonstration [PDF]

Royal Society Open Science, 2020
Improvements in the design of pedestrian facilities have reduced the frequency of crowd accidents, and safety is now generally ensured in well-planned crowd events. However, congestion and inefficient use of infrastructures still remain an issue.
Hisashi Murakami, Claudio Feliciani, Kenichiro Shimura, Katsuhiro Nishinari   +3 more
doaj   +1 more source

Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant

Viruses, 2021
Mutations in HBsAg, the surface antigen of the hepatitis B virus (HBV), might affect the serum HBV DNA level of HBV-infected patients, since the reverse transcriptase (RT) domain of HBV polymerase overlaps with the HBsAg-coding region.
Md. Golzar Hossain, Yadarat Suwanmanee, Kaili Du, Keiji Ueda   +3 more
doaj   +1 more source

Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress

mBio, 2023
Members of the Apicomplexa phylum possess specialized secretory organelles that discharge, apically and in a timely regulated manner, key factors implicated in parasite motility, host cell invasion, egress and subversion of host cellular functions.
David J. Dubois, Sylia Chehade, Jean-Baptiste Marq, Kannan Venugopal, Bohumil Maco, Albert Tell I. Puig, Dominique Soldati-Favre, Sabrina Marion   +7 more
doaj   +1 more source

Exogenous nitric oxide stimulates early egress of Eimeria tenella sporozoites from primary chicken kidney cells in vitro

Parasite, 2021
Egress plays a vital role in the life cycle of apicomplexan parasites including Eimeria tenella, which has been attracting attention from various research groups.
Yan Xinlei, Han Wenying, Liu Xianyong, Suo Xun   +3 more
doaj   +1 more source

A Signaling Factor Linked to Toxoplasma gondii Guanylate Cyclase Complex Controls Invasion and Egress during Acute and Chronic Infection

mBio, 2022
Toxoplasma gondii is an intracellular apicomplexan parasite that relies on cyclic GMP (cGMP)-dependent signaling to trigger timely egress from host cells in response to extrinsic and intrinsic signals.
Shu Ye, Matteo Lunghi, Dominique Soldati-Favre   +2 more
doaj   +1 more source

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

eLife, 2021
Toxoplasma gondii is an important human pathogen infecting an estimated one in three people worldwide. The cytokine interferon gamma (IFNγ) is induced during infection and is critical for restricting T. gondii growth in human cells. Growth restriction is
Nicholas Rinkenberger, Michael E Abrams, Sumit K Matta, John W Schoggins, Neal M Alto, L David Sibley   +5 more
doaj   +1 more source