Results 1 to 10 of about 3,237 (126)

Ehrlichia chaffeensis Co-Opts Phagocytic Hemocytes for Systemic Dissemination in the Lone Star Tick, Amblyomma americanum [PDF]

Journal of Innate Immunity, 2023
Introduction: Hematophagous arthropods can acquire and transmit several pathogens of medical importance. In ticks, the innate immune system is crucial in the outcome between vector-pathogen interaction and overall vector competence. However, the specific
Abdulsalam Adegoke, Julia Hanson, Ryan C. Smith, Shahid Karim   +3 more
doaj   +2 more sources

Antibody reactive immunomes of Ehrlichia chaffeensis and E. canis are diverse and defined by conformational antigenic determinants [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
For decades, the defined antibody reactive proteins of Ehrlichia chaffeensis and E. canis were limited to a small group with linear antibody epitopes.
Tian Luo, Jignesh G. Patel, Xiaofeng Zhang, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride   +7 more
doaj   +2 more sources

Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis [PDF]

mBio, 2022
Ehrlichia chaffeensis, an obligatory intracellular bacterium, causes human monocytic ehrlichiosis, an emerging disease transmitted by the Lone Star tick, Amblyomma americanum. Here, we investigated the vaccine potential of OMP-1B and VirB2-4.
Khemraj Budachetri, Mingqun Lin, Rory C. Chien, Wenqing Zhang, Guy Nathaniel Brock, Yasuko Rikihisa   +5 more
doaj   +2 more sources

Glutathione Synthesis Regulated by CtrA Protects Ehrlichia chaffeensis From Host Cell Oxidative Stress [PDF]

Frontiers in Microbiology, 2022
Ehrlichia chaffeensis, a small Gram-negative obligatory intracellular bacterium, infects human monocytes or macrophages, and causes human monocytic ehrlichiosis, one of the most prevalent, life-threatening emerging zoonoses.
Jiaqi Yan, Qi’an Liang, Zhouyi Chai, Nan Duan, Xiaoxiao Li, Yajing Liu, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng   +11 more
doaj   +2 more sources

The “Biological Weapons” of Ehrlichia chaffeensis: Novel Molecules and Mechanisms to Subjugate Host Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging, potentially fatal tick-borne infectious disease.
Yasuko Rikihisa
doaj   +2 more sources

CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance to Ehrlichia chaffeensis [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis (HME), is a Gram-negative obligatory intracellular bacterium, which infects and multiplies in human monocytes and macrophages.
Qi’an Liang, Jiaqi Yan, Shuwen Zhang, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng   +8 more
doaj   +2 more sources

Transmission of Ehrlichia chaffeensis From an Organ Donor to a Kidney-Pancreas Transplant Recipient. [PDF]

Transpl Infect Dis
Transplant Infectious Disease, Volume 27, Issue 5, September/October 2025.
Gundelly P, Ransom E, Stewart Z, Ruch B, Jittirat A, Denny L, Kasten J, Taylor ML, Salzer JS, Basavaraju SV, Annambhotla P, McCormick DW, Gleaton AN, Karpathy SE, Singleton J, Ramos C, Paddock CD, Rothfeldt LK, Baker M, Villalba JA.   +19 more
europepmc   +2 more sources

Ehrlichia chaffeensis TRP120 ubiquitinates tumor suppressor APC to modulate Hippo and Wnt signaling [PDF]

Frontiers in Cell and Developmental Biology
Ehrlichia chaffeensis: TRP120 is a multifunctional effector that acts as a ligand mimic to activate evolutionary conserved eukaryotic signaling pathways Notch, Wnt, Hedgehog and Hippo.
Caitlan D. Byerly, Bing Zhu, Paityn A. Warwick, LaNisha L. Patterson, Nicholas A. Pittner, Jere W. McBride   +5 more
doaj   +2 more sources

Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy

Frontiers in Cellular and Infection Microbiology, 2016
Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis.
Tierra R Farris, Tian Luo, Shubhajit Mitra   +2 more
exaly   +3 more sources

Ehrlichia chaffeensis EplA Interaction With Host Cell Protein Disulfide Isomerase Promotes Infection [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Ehrlichia chaffeensis is an obligate intracellular bacterium that invades monocytes to cause the emerging and potentially severe disease, monocytic ehrlichiosis.
Ryan S. Green, Jerilyn R. Izac, Waheeda A. Naimi, Nathaniel O'Bier, Edward B. Breitschwerdt, Richard T. Marconi, Jason A. Carlyon   +6 more
doaj   +2 more sources