Results 81 to 90 of about 33,480 (278)

The Role of Eicosanoids in Gynecological Malignancies

Frontiers in Pharmacology, 2020
Eicosanoids, bio-active lipid molecules, evoke a multitude of biological effects that directly affect cancer cells and indirectly affect tumor microenvironment.
Paige G. Smith, Dana Roque, Dana Roque, Mc Millan Ching, Amy Fulton, Amy Fulton, Amy Fulton, Gautam Rao, Gautam Rao, Jocelyn C. Reader, Jocelyn C. Reader   +10 more
doaj   +1 more source

Relationship between a Common Variant in the Fatty Acid Desaturase (FADS) Cluster and Eicosanoid Generation in Humans*

Journal of Biological Chemistry, 2014
Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear.
Austin G. Hester, R. Murphy, Charis Uhlson, P. Ivester, Tammy C. Lee, S. Sergeant, Leslie R. Miller, T. Howard, R. Mathias, F. Chilton   +9 more
semanticscholar   +1 more source

Intravenous Lipid Emulsions to Deliver Bioactive Omega-3 Fatty Acids for Improved Patient Outcomes

Marine Drugs, 2019
Lipids used in intravenous nutrition support (i.e., parenteral nutrition) provide energy, building blocks, and essential fatty acids. These lipids are included as emulsions since they need to be soluble in an aqueous environment.
Philip C. Calder
doaj   +1 more source

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America, 2014
Significance Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is widely viewed as the primary enzyme responsible for inflammatory arachidonic acid (AA) release and with high specificity.
Paul C. Norris, D. Gosselin, D. Reichart, C. Glass, E. Dennis   +4 more
semanticscholar   +1 more source

Eicosanoids in Metabolic Syndrome [PDF]

, 2013
Chronic persistent inflammation plays a significant role in disease pathology of cancer, cardiovascular disease, and metabolic syndrome (MetS). MetS is a constellation of diseases that include obesity, diabetes, hypertension, dyslipidemia, hypertriglyceridemia, and hypercholesterolemia.
Andrew Esterle, John Y.L. Chiang, Mohamed A. Abdelmegeed, Yoon Kwang Lee, William M. Chilian, Katie Eckman, Byoung-Joon Song, James P. Hardwick   +7 more
openaire   +3 more sources

Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia

Aging Cell, EarlyView.
During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu, Tianmou Zhu, Hongmei Mou, Shumin Tan, John M. Leong   +4 more
wiley   +1 more source

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, EarlyView.
Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu, Changhan Chen, Wuping Liu, Zhixiang Zhao, Yuhua Fan, Zhenjiang Li, Weilun Huang, Tingting Xie, Cheng Luo, Zhouzhou Yao, Qi Guo, Zhiyu Yang, Juan Liu, Yujin Zhang, Rodney E. Kellems, Jian Xia, Ji Li, Yang Xia   +17 more
wiley   +1 more source

Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology1[S]

Journal of Lipid Research, 2009
Eicosanoids have been implicated in a vast number of devastating inflammatory conditions, including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different eicosanoids have been identified, with many having potent bioactive ...
Matthew W. Buczynski, Darren S. Dumlao, Edward A. Dennis   +2 more
doaj  

Immunosuppressive Activities of Novel PLA₂ Inhibitors from Xenorhabdus hominickii, an Entomopathogenic Bacterium

Insects, 2020
Eicosanoids mediate both cellular and humoral immune responses in insects. Phospholipase A2 (PLA2) catalyzes the first committed step in eicosanoid biosynthesis.
Md. Mahi Imam Mollah, Aman Dekebo, Yonggyun Kim   +2 more
doaj   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

The FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu, Yue Gao, Marcin Luzarowski, Elisabeth Seebach, Thomas Heitkamp, Michael Börsch, Thomas Ruppert, Katharina F. Kubatzky   +7 more
wiley   +1 more source