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Eicosanoids in inflammation in the blood and the vessel
Frontiers in Pharmacology, 2022 Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi +3 more
exaly +4 more sources
Eicosanoids and Oxidative Stress in Diabetic Retinopathy
Antioxidants, 2020 Oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (DR) because the retina has high vascularization and long-time light exposition.
George Hsiao, Mohamed Al-Shabrawey
exaly +4 more sources
Essays in Biochemistry, 2020 This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action of eicosanoids in different physiological systems, the roles of eicosanoids in selected diseases, and the major inhibitors of eicosanoid synthesis and action ...
Phillip C Calder
exaly +3 more sources
Eicosanoids: Atherosclerosis and cardiometabolic health
Journal of Clinical & Translational Endocrinology, 2020 Cardiovascular diseases (CVD) have been the leading causes of death in the U.S. for nearly a century. Numerous studies have linked eicosanoids to cardiometabolic disease.
Kimberly Piper, Mahdi Garelnabi
doaj +2 more sources
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
Cell, 2020 Summary Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown.
Nikos Koundouros +2 more
exaly +2 more sources
Therapeutic Advances in Gastroenterology, 2020 Background: Eicosanoid and related docosanoid polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives have been proposed as noninvasive lipidomic biomarkers of nonalcoholic steatohepatitis (NASH).
Cyrielle Caussy +9 more
doaj +2 more sources
Eicosanoids in Cancer: New Roles in Immunoregulation
Frontiers in Pharmacology, 2020 Eicosanoids represent a family of active biolipids derived from arachidonic acid primarily through the action of cytosolic phospholipase A2-α.
Emily K Kleczko, Raphael A Nemenoff
exaly +2 more sources
Clinics, 2018 Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and ...
Renata Nascimento Gomes +2 more
doaj +2 more sources
PLoS Medicine, 2020 BackgroundInflammation during pregnancy is hypothesized to influence fetal growth. Eicosanoids, an important class of lipid mediators derived from polyunsaturated fatty acids, can act as both direct influences and biomarkers of inflammation through a ...
Barrett M Welch +2 more
exaly +3 more sources
Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of eicosanoids
Frontiers in Physiology, 2016 Candida albicans is commonly found in mixed infections with Pseudomonas aeruginosa, especially in the lungs of cystic fibrosis patients. Both of these opportunistic pathogens are able to form resistant biofilms and frequently infect immunocompromised ...
Ruan eFourie +6 more
doaj +2 more sources