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Essays in Biochemistry, 2020 Abstract This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action of eicosanoids in different physiological systems, the roles of eicosanoids in selected diseases, and the major inhibitors of eicosanoid synthesis and action. Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids
Phillip C Calder
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Eicosanoids in inflammation in the blood and the vessel
Frontiers in Pharmacology, 2022 Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi +3 more
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Eicosanoids and Oxidative Stress in Diabetic Retinopathy
Antioxidants, 2020 Oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (DR) because the retina has high vascularization and long-time light exposition.
George Hsiao, Mohamed Al-Shabrawey
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Infection and Immunity, 2021 Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), allow the innate immune cells to respond rapidly to bacterial ...
Austin E Sheppe, Mariola J Edelmann
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Therapeutic Advances in Gastroenterology, 2020 Background: Eicosanoid and related docosanoid polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives have been proposed as noninvasive lipidomic biomarkers of nonalcoholic steatohepatitis (NASH).
Cyrielle Caussy +9 more
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PLoS Medicine, 2020 BACKGROUND:Inflammation during pregnancy is hypothesized to influence fetal growth. Eicosanoids, an important class of lipid mediators derived from polyunsaturated fatty acids, can act as both direct influences and biomarkers of inflammation through a ...
Barrett M Welch +8 more
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Lung eicosanoids in perinatal rats with congenital diaphragmatic hernia [PDF]
Mediators of Inflammation, 1997 Abnormal levels of pulmonary eicosanoids have been reported in infants with persistent pulmonary hypertension (PPH) and congenital diaphragmatic hernia (CDH).
H. Ijsselstijn +4 more
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Eicosanoids: Atherosclerosis and cardiometabolic health
Journal of Clinical & Translational Endocrinology, 2020 Cardiovascular diseases (CVD) have been the leading causes of death in the U.S. for nearly a century. Numerous studies have linked eicosanoids to cardiometabolic disease.
Kimberly Piper, Mahdi Garelnabi
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Clinics, 2018 Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and ...
Renata Nascimento Gomes +2 more
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Stress, inflammation, and eicosanoids: an emerging perspective
Cancer and Metastasis Reviews, 2018 Sujanitha Umamaheswaran +2 more
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