Results 11 to 20 of about 815 (103)

Open label clinical trial of orally administered molnupiravir as a first‐line treatment for naturally occurring effusive feline infectious peritonitis [PDF]

Journal of Veterinary Internal Medicine
Background Before the discovery of effective antiviral drugs, feline infectious peritonitis (FIP) was a uniformly fatal disease of cats. Multiple antiviral treatments have been recognized, but optimization of treatment protocols is needed.
Krystle L. Reagan, Terza Brostoff, Jully Pires, Amy Rose, Diego Castillo, Brian G. Murphy   +5 more
doaj   +3 more sources

Correction: Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose. [PDF]

RSC Adv, 2022
Correction for ‘Conversion of N -acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose’ by Ajaz Ahmed et al. , RSC Adv. , 2021, 11
Ahmed A, Ahmed QN, Mukherjee D.
europepmc   +2 more sources

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets. [PDF]

Nat Microbiol, 2021
The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic impact on human health1. Widespread community transmission has triggered stringent distancing measures with severe socio-economic consequences. Gaining control of the pandemic will depend on the interruption of transmission chains until vaccine-induced or naturally acquired ...
Cox RM, Wolf JD, Plemper RK.
europepmc   +4 more sources

Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose. [PDF]

RSC Adv, 2021
A method for the preparation of molnupiravir (EIDD-2801) via regioselective conversion of an N -acyl-nucleoside intermediate, generated through stereoselective glycosylation of protected ribose and N 4
Ahmed A, Ahmed QN, Mukherjee D.
europepmc   +4 more sources

Therapeutic MK-4482/EIDD-2801 Blocks SARS-CoV-2 Transmission in Ferrets [PDF]

, 2020
Abstract The COVID-19 pandemic is having a catastrophic impact on human health. Widespread community transmission has triggered stringent distancing measures with severe socioeconomic consequences. Gaining control of the pandemic will depend on interruption of transmission chains until protective herd immunity arises.
Plemper R, Cox R, Wolf J.
europepmc   +3 more sources

Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2 [PDF]

Trials, 2021
A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the ...
Wendy Holman, Wayne Holman, Stacy McIntosh, Wendy Painter, George Painter, Jim Bush, Oren Cohen   +6 more
doaj   +2 more sources

Accelerated First-in-Human Clinical Trial of EIDD-2801/MK-4482 (molnupiravir), a Ribonucleoside Analogue with Potent Antiviral Activity Against SARS-CoV-2 [PDF]

Trials, 2021
Abstract A recently published article described the safety, tolerability and pharmacokinetic profile of molnupiravir, a novel antiviral agent with potent activity against SARS-CoV-2, the causative agent of COVID-19. Here, we report an unprecedented collaboration between sponsor, contract research organization (CRO) and regulatory authorities ...
Cohen O, Holman W, Holman W, Painter W, McIntosh S, Painter G, Bush J.   +6 more
europepmc   +4 more sources

A concise route to MK-4482 (EIDD-2801) from cytidine†

Chemical Communications, 2020
A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine.
Till Opatz, Grace P Ahlqvist, Timothy F. Jamison   +2 more
exaly   +6 more sources

Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801 [PDF]

, 2020
Abstract All known recently emerged human coronaviruses likely originated in bats. Here, we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2) and two highly relevant endogenous pre-pandemic SARS-like ...
Wahl A, Gralinski L, Johnson C, Yao W, Kovarova M, Dinnon K, Liu H, Madden V, Krzystek H, De C, White K, Schäfer A, Zaman T, Leist S, Grant P, Gully K, Askin F, Browne E, Jones C, Pickles R, Baric R, Garcia JV.   +21 more
europepmc   +3 more sources

Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences [PDF]

Bulletin of the National Research Centre, 2022
Background The study was aimed at encapsulating the evidence of in vitro and in vivo antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2, the pathogen responsible for COVID-19, and finding out the efficacy and ...
Shivali Singla, Sachin Goyal
doaj   +2 more sources