A High‐Yielding Synthesis of EIDD‐2801 from Uridine** [PDF]
European Journal of Organic Chemistry, 2020 A simple reordering of the reaction sequence allowed the improved synthesis of EIDD-2801, an antiviral with promising activity against the SARS-CoV-2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17% to 61%, and fewer isolation/purification steps were needed.
Sándor Balázs Ötvös +2 more
exaly +5 more sources
SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 [PDF]
Nature, 2021 All known recently emerged human coronaviruses probably originated in bats1. Here we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) and two highly relevant endogenous pre-pandemic SARS-like bat ...
Kendra Gully +2 more
exaly +5 more sources
Evaluation of molnupiravir (EIDD-2801) efficacy against SARS-CoV-2 in the rhesus macaque model [PDF]
Antiviral Research, 2023 Molnupiravir (EIDD-2801) is a prodrug of a ribonucleoside analogue that is currently being used under a US FDA emergency use authorization for the treatment of mild to moderate COVID-19. We evaluated molnupiravir for efficacy as an oral treatment in the rhesus macaque model of SARS-CoV-2 infection.
Alejandro Villasante Tezanos +2 more
exaly +4 more sources
Broad-Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses. [PDF]
MedComm (2020)MedComm, Volume 6, Issue 5, May 2025.
Yang S, Li K, Zhou Q, Zhang X, Guo D.
europepmc +2 more sources
Pharmacokinetics of Molnupiravir in Cats with Naturally Occurring Feline Infectious Peritonitis [PDF]
PathogensAntiviral drugs like EIDD-2801 (molnupiravir; MPV) have been successfully used in the treatment of feline infectious peritonitis (FIP). The previous study of the pharmacokinetics of MPV in healthy cats showed promise for its use and safety. The objective
Petra Černá +5 more
doaj +2 more sources
Efficacy of small molecules against the severe acute respiratory syndrome coronavirus 2 XBB1.16 and XBB1.9.2.1. [PDF]
MedComm (2020)MedComm, Volume 5, Issue 3, March 2024.
Yuan L, Liu X, Li S, Zhong W, Xia N.
europepmc +2 more sources
Clinical trial of molnupiravir with or without an oral immune stimulant as a first-line treatment of feline infectious peritonitis [PDF]
Journal of Feline Medicine and SurgeryObjectives The aim of the present study was to evaluate the efficacy of oral molnupiravir (MPV; EIDD-2801) in cats with naturally occurring feline infectious peritonitis (FIP), with a subset of cats being administered a known immune stimulant (liposome ...
Petra Černá +4 more
doaj +2 more sources
Correction: Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose. [PDF]
RSC Adv, 2022 Correction for ‘Conversion of N -acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose’ by Ajaz Ahmed et al. , RSC Adv. , 2021, 11
Ahmed A, Ahmed QN, Mukherjee D.
europepmc +2 more sources
Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose. [PDF]
RSC Adv, 2021 A method for the preparation of molnupiravir (EIDD-2801) via regioselective conversion of an N -acyl-nucleoside intermediate, generated through stereoselective glycosylation of protected ribose and N 4
Ahmed A, Ahmed QN, Mukherjee D.
europepmc +4 more sources
Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets. [PDF]
Nat Microbiol, 2021 The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic impact on human health1. Widespread community transmission has triggered stringent distancing measures with severe socio-economic consequences. Gaining control of the pandemic will depend on the interruption of transmission chains until vaccine-induced or naturally acquired ...
Cox RM, Wolf JD, Plemper RK.
europepmc +4 more sources