Results 31 to 40 of about 809 (101)
Viruses, 2022 Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and affordable vaccines or antiviral therapeutics. The disease has a spectrum of clinical presentations including an effusive (“wet”) form and non-effusive (“dry”
Sarah Cook +10 more
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Perspectives for antivirals to limit SARS-CoV-2 infection (COVID-19) [PDF]
Microbiology Australia, 2021 Compared with vaccines, antivirals for curbing COVID-19 (SARS-CoV-2 infection) have been developed at a much lower pace. Favipiravir has proven efficacious (in hamsters) but only at a very high dose which may not be feasible in humans.
Erik De Clercq
doaj
International Journal of Endorsing Health Science Research, 2022 Background: The SARS-COV-2's spread from continent to the continent has resulted in an increased number of mutations in the viral gene encoding proteins.
Arsalan Rasheed +9 more
doaj +3 more sources
Molnupiravir Does Not Induce Mutagenesis in Host Lung Cells during SARS-CoV-2 Treatment
Bioinformatics and Biology Insights, 2022 As SARS-CoV-2 continues to evolve and spread with the emergence of new variants, interest in small molecules with broad-spectrum antiviral activity has grown.
John Maringa Githaka
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Heliyon, 2021 Safe and effective oral formulation of a drug, that is easy to store, transport, and administer, is imperative to reach the masses including those without adequate facilities and resources, in order to combat globally transmitted coronavirus disease 2019
Chaitanya N. Hiremath
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Frontiers in Pharmacology, 2020 The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health.
Zhonglei Wang, Zhonglei Wang, Liyan Yang
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A Stereoselective Synthesis of 4′‐α‐Fluoro‐methyl Carbocyclic Nucleoside Analogs
ChemistrySelect, Volume 8, Issue 26, July 14, 2023., 2023 The article reports the synthesis of 4′‐fluoro‐methyl‐carbocyclic nucleoside analogs. The described procedure may open new synthetic avenues for the derivatization at the 4′‐position of carbocyclic nucleosides. 4′‐modified nucleoside analogs have not been well explored for biological activities, and their evaluation as antiviral and anticancer agents ...
Uma S. Singh +5 more
wiley +1 more source
Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2
MedComm, Volume 4, Issue 3, June 2023., 2023 In this review, authors provide a comprehensive overview of various identified pathogenic targets and pathways, as well as corresponding repurposed approved/clinical drugs and their potential against COVID‐19. Moreover, authors summarizenumerous potential pathogenic targets associated with viral life cycle and virus–host cell communication, repurposed ...
Yiying Xue +6 more
wiley +1 more source
Frontiers in Pharmacology, 2022 As of October 2021, neither established agents (e.g., hydroxychloroquine) nor experimental drugs have lived up to their initial promise as antiviral treatment against SARS-CoV-2 infection.
Verena Schöning +6 more
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Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases
Advanced Science, Volume 9, Issue 35, December 19, 2022., 2022 Gossypol is identified as an effective inhibitor against SARS‐CoV‐2 RNA‐dependent RNA polymerases. It exhibits excellent antiviral activity against SARS‐CoV‐2 and its variants of concern as well as all examined viruses from the four main phylogenetic branches of coronaviruses, which makes gossypol a novel broad‐spectrum anti‐coronavirus inhibitor that ...
Wenjing Wang +13 more
wiley +1 more source