Results 31 to 40 of about 15,176 (154)

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

Journal of Biological Chemistry, 1993
Charles E. Samuel
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Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.

Journal of Biological Chemistry, 1992
Inhibition of protein synthesis in rabbit reticulocyte lysates occurs in response to a variety of conditions including heme deficiency, addition of oxidants, and heat stress. The inhibition of translation is due to the activation of a heme-regulated protein kinase (HRI) which specifically phosphorylates the alpha-subunit of the eukaryotic initiation ...
Robert L. Matts, Zuojun Xu, Jayanta K. Pal, J.J. Chen   +3 more
openalex   +3 more sources

Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae. [PDF]

Molecular and Cellular Biology, 1994
Previous studies have demonstrated that the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha), encoded by the SUI2 gene in the yeast Saccharomyces cerevisiae, is phosphorylated at Ser-51 by the GCN2 kinase in response to general amino acid control.
Lan Feng, Haejin Yoon, Thomas F. Donahue
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Kinetics of Phosphorylation of eIF-2 by the hemin-controlled repressor and casein kinase II. Inhibition by hemin and 2,3-diphosphoglyceric acid.

Journal of Biological Chemistry, 1982
The kinetics of phosphorylation of eukaryotic initiation factor 2 (eIF-2) by two cyclic nucleotide-independent protein kinases from rabbit reticulocytes have been studied. The hemin-controlled repressor (HCR) and casein kinase II phosphorylate the alpha and beta subunits of eIF-2, respectively.
Mary Isabel Gonzatti, Jolinda A. Traugh
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Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway

Journal of Animal Science and Biotechnology, 2012
Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the postprandial rise in insulin and amino acids, especially leucine. The mechanism of leucine's action in vivo is not well understood. In
Suryawan Agus, Nguyen Hanh V, Almonaci Rosemarie D, Davis Teresa A   +3 more
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Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus

Journal of Immunology Research, 2015
Previous studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) from patients with systemic lupus erythematosus (SLE) exhibited the phenomenon of apoptosis.
Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng Gu   +6 more
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Phospholipid‐sensitive Ca²⁺‐dependent protein kinase phosphorylates the β subunit of eukaryotic initiation factor 2 (eIF‐2) [PDF]

FEBS Letters, 1983
The ability of homogeneous phospholipid‐sensitive Ca2+‐dependent protein kinase (PL‐Ca‐PK) from pig spleen to phosphorylate eukaryotic initiation factor 2 (eIF‐2) was examined. PL‐Ca‐PK phosphorylated the β‐subunit of eIF‐2, whereas myosin light chain kinase (MLCK) and cyclic AMP‐ and cyclic GMP‐dependent protein kinases (cA‐PK and cG‐PK) did not.
Schatzman, Randall C., Grifo, Jamie A., Merrick, William C., Kuo, J.F.   +3 more
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Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissues⃞

Journal of Lipid Research, 2008
Obesity and insulin resistance are independent risk factors for metabolic syndrome, diabetes, and cardiovascular disease. Adipose tissue samples from nonobese (NO), insulin-sensitive obese (ISO), and insulin-resistant obese (IRO) subjects from ...
R. MacLaren, W. Cui, S. Simard, K. Cianflone   +3 more
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Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

PLoS ONE, 2011
BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter.
Gerard Ill-Raga, Ernest Palomer, Matthew A Wozniak, Eva Ramos-Fernández, Mònica Bosch-Morató, Marta Tajes, Francesc X Guix, José J Galán, Jordi Clarimón, Carmen Antúnez, Luis M Real, Mercé Boada, Ruth F Itzhaki, César Fandos, Francisco J Muñoz   +14 more
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Application of the Mass Spectrometry-High-Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas. [PDF]

Biomed Chromatogr
ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Louati K, Kolsi F, Mellouli M, Louati H, Kallel R, Zribi R, Borni M, Hakim LS, Maalej A, Choura S, Chamkha M, Sayadi S, Khemakhem Z, Boudawara TS, Boudawara MZ, Zribi K, Safta F.   +16 more
europepmc   +2 more sources