Results 121 to 130 of about 35,642 (231)

Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation [PDF]

, 2014
Margarito Rojas, Anne‐Claude Gingras, Thomas Dever   +2 more
openalex   +1 more source

Data from eIF2α Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1α

, 2023
Andreas I. Papadakis, Efrosyni Paraskeva, Philippos Peidis, Hala Muaddi, Suiyang Li, Leda Raptis, Kostas Pantopoulos, George Simos, Antonis E. Koromilas   +8 more
openalex   +1 more source

UGA4 and YBR062C Regulate Oxidative Stress Tolerance Under Heavy Metal Toxicity

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Under heavy metal stress, global cap‐dependent translation is compromised. However, expression of URE2, a key gene involved in cellular tolerance to heavy metal toxicity, is maintained through an internal ribosome entry site (IRES)–mediated mode of translation.
Mustafa Al‐gafari, Houman Moteshareie, Thomas D. D. Kazmirchuk, Jiashu Wang, Sarah Takallou, Parvin Khosravifar, Mohsen Hooshyar, Bahram Samanfar, Ashkan Golshani   +8 more
wiley   +1 more source

氧乐果导致染毒大鼠内质网应激的研究

Zhongguo shiyan zhenduanxue, 2018
目的研究有机磷暴露接触对内质网的影响。方法大鼠持续60天氧乐果经口染毒,检测骨骼肌中的PERK,BiP,p-eIF2α,eIF2α,IRE1α的表达水平。结果染毒组的BiP,PERK和IRE1α的表达水平均高于Control组 ...
刘霖霖, 庄传宁, 熊书晗, 孟繁竹, 吴秀丽   +4 more
doaj  

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, Volume 13, Issue 17, 23 March 2026.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer

The EMBO Journal
Protein synthesis is an essential process, deregulated in multiple tumor types showing differential dependence on translation factors compared to untransformed tissue.
Ivana Paskov Škapik, Chiara Giacomelli, Sarah Hahn, Hanna Deinlein, Peter Gallant, Mathias Diebold, Josep Biayna, Anne Hendricks, Leon Olimski, Christoph Otto, Carolin Kastner, Elmar Wolf, Christina Schülein-Völk, Katja Maurus, Andreas Rosenwald, Nikolai Schleussner, Rene-Filip Jackstadt, Nicolas Schlegel, Christoph-Thomas Germer, Martin Bushell, Martin Eilers, Stefanie Schmidt, Armin Wiegering   +22 more
doaj   +1 more source

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs) [PDF]

, 2020
Tiffany J. Rios-Fuller, Mélanie Mahé, Beth Walters, Dounia Abbadi, Sandra Pérez-Baos, Abhilash Gadi, John J. Andrews, Olga Katsara, C. Theresa Vincent, Robert J. Schneider   +9 more
openalex   +1 more source

Characterization of Immune Infiltrating Cells in Bladder Urothelial Carcinoma and Its Clinical Significance

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Immune cells have been linked to the initiation and progression of tumors, and their presence is often used to predict disease prognosis. However, when it comes to bladder urothelial carcinoma (BLCA), there has not been a comprehensive investigation into the function and prognostic value of different immune cell types.
Xin Yan, Xiaoyu Tang, Linfa Guo, Ziqi He, Shaoxi Liu, Shaojie Wu, Zhilong Li, Tong‐Zu Liu, Hang Zheng, Weibing Zhang, Sheng Li   +10 more
wiley   +1 more source

Integration of single‐cell and bulk transcriptomics reveals the association of manganese metabolism‐related genes with prognosis and immune infiltration in lung adenocarcinoma

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
This study developed a prognostic model for lung adenocarcinoma using manganese metabolism‐related genes (MRGs). Nine key MRGs were identified via multi‐omics and LASSO‐Cox analyses to calculate a risk score. The model showed robust predictive performance in both training and validation cohorts.
Hongliang Li, Shuzhen Wei, Wei Li, Junxia Sun, Yi Wang   +4 more
wiley   +1 more source

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species.

PLoS Pathogens, 2016
Entamoeba histolytica is an enteric pathogen responsible for amoebic dysentery and liver abscess. It alternates between the host-restricted trophozoite form and the infective environmentally-stable cyst stage. Throughout its lifecycle E.
Holland M Hendrick, Brenda H Welter, Matthew A Hapstack, Steven E Sykes, William J Sullivan, Lesly A Temesvari   +5 more
doaj   +1 more source