Results 31 to 40 of about 35,642 (231)

Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]

, 2018
While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy, Fan, Yao, Jalali, Aydin, Li, Bai-Yan, Liu, Shengzhi, Minami, Kazumasa, Nakshatri, Harikrishna, Ogawa, Kazuhiko, Yokota, Hiroki   +8 more
core   +1 more source

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. [PDF]

, 2015
Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013).
Ingolia, Nicholas T, McGeachy, Anna M, Sidrauski, Carmela, Walter, Peter   +3 more
core   +2 more sources

Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling

Frontiers in Molecular Neuroscience, 2022
ObjectiveCisplatin is a broad-spectrum anti-tumour drug commonly used in clinical practice. However, its ototoxicity greatly limits its clinical application, and no effective method is available to prevent this effect.
Wen Lu, Kun Ni, Kun Ni, Zhuangzhuang Li, Lili Xiao, Yini Li, Yumeng Jiang, Jincheng Zhang, Haibo Shi   +8 more
doaj   +1 more source

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

Frontiers in Oncology, 2022
We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a ...
Karin Eytan, Ziv Versano, Ziv Versano, Roni Oren, Jasmine Jacob-Hirsch, Jasmine Jacob-Hirsch, Moshe Leitner, Alon Harmelin, Gideon Rechavi, Gideon Rechavi, Gideon Rechavi, Amos Toren, Amos Toren, Shoshana Paglin, Michal Yalon, Michal Yalon   +15 more
doaj   +1 more source

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]

, 2017
Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac, A Castegna, A Chakrabarty, A Dasgupta, A Fogli, A Lau, A Martín, A Massie, A Massie, A Massie, A Mehta, A Prez-Samart¡n, A Tisell, A Vallejo-Illarramendi, AC Rimaniol, Ann Massie, AS Basso, Axel Methner, AY Shih, B Fogal, C Kilkenny, C Larochelle, C Matute, C Nathan, Cathy Jensen, D Bundel De, D Offen, D Piani, D Pitt, D Pitt, D Zhai, DA Baker, DA Hafler, E Merckx, EA McCullagh, Eduard Bentea, Ellen Merckx, F Loria, FN Soria, G Angelini, G Grasselli, G Sulkowski, G Sulkowski, GC Mc, Geert van Loo, Giulia Albertini, H Broholm, H Gmunder, H Hardin-Pouzet, H Sato, H Sato, H Sato, H Sato, H Sato, Hideyo Sato, I Gutcher, IE Morales Pantoja, IR Stojanovic, J Al-Omaishi, J Lewerenz, J Lewerenz, J Lewerenz, J Liefferinge Van, J Newcombe, JA Ellerhorst, Jacques De Keyser, Jan Lewerenz, JF Stover, JJ Geurts, JJ Hendriks, Joeri Van Liefferinge, K Mitosek-Szewczyk, KE Hill, KJ Smith, KS Evonuk, Lauren Deneyer, Lise Verbruggen, LM Sayre, M Kursar, M Naegele, M Ohgoh, M Penkowa, M Vercellino, Magdalena Paterka, Michael Dietrich, O Ciccarelli, O Maguire, O Pampliega, P Gadangi, P Maher, P Sarchielli, P Sarchielli, P Valk van der, P Werner, Pamela Maher, Philipp Albrecht, PW Gout, R Bridges, R Pacheco, R Srinivasan, RJ Bridges, S Bannai, S Chintala, S Licht-Mayer, T Smith, Thomas Demuyser, W Droge, Y Ganor, Y Gilgun-Sherki, Y He, Y He   +110 more
core   +2 more sources

Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis

Journal of Biomedical Science, 2023
Background Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as an antioxidant. However, there is
Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung, David K. Ann   +6 more
doaj   +1 more source

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source

Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2

Frontiers in Microbiology, 2021
Duck hepatitis A virus type 1 (DHAV-1) is one of the most deadly pathogens that endanger the duck industry. Most viruses usually turn off host translation after infection to facilitate viral replication and translation.
Yuanzhi Liu, Yuanzhi Liu, Yuanzhi Liu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Qun Gao, Qun Gao, Qun Gao, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Renyong Jia, Renyong Jia, Renyong Jia, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Yanling Yu, Yanling Yu, Yanling Yu, Yunya Liu, Yunya Liu, Yunya Liu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan   +56 more
doaj   +1 more source

IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy [PDF]

, 2018
Sensors of endoplasmic reticulum (ER) stress function in a co-ordinated manner. In the present study we investigated the relationship between IRE1α and PERK pathways and survival of ER stressed U937 cells and BC3 cells. To this end, we investigated the
Alfano, Vincenzo, Carbotta, Sabino, Di Renzo, Livia, Ferretti, Elisabetta, Storniolo, Antonello   +4 more
core   +2 more sources