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Rapid Radiations and the Race to Redundancy: An Investigation of the Evolution of Australian Elapid Snake Venoms [PDF]

Toxins, 2016
Australia is the stronghold of the front-fanged venomous snake family Elapidae. The Australasian elapid snake radiation, which includes approximately 100 terrestrial species in Australia, as well as Melanesian species and all the world's true sea snakes, may be less than 12 million years old..
Timothy Jackson, Bryan Fry, Christina N Zdenek   +2 more
exaly   +7 more sources

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ACETYLCHOLINESTERASE ISOZYMES FROM ELAPID VENOMS

1978
W B Elliott
exaly   +2 more sources

Further studies on the mass of venom injected by Elapid snakes

Toxicon, 1983
Further experimental studies to determine the mass of venom injected by medically-significant Australian elapids are reported. The use of a modified enzyme immunoassay technique to measure venom injected during snake bite is presented. The feeding biting pattern of the Australian eastern brown snake (Pseudonaja textilis) is described.
J J, Morrison, J H, Pearn, N T, Charles, A R, Coulter   +3 more
openaire   +2 more sources

Identification and discrimination of snake venoms from Egyptian elapids

Toxicon, 2013
The avidity to the corresponding antigens is often higher than to the cross-reactive antigens. This was demonstrated with the highly cross-reactive elapid Egyptian snake venoms Naja haje (Nh), Naja nigricollis (Nn) and Walterinnesia aegyptia (Wa), and used for the differentiation among the three species in a simple ELISA-based assay.
Nihal M, Ibrahim, Ebtsam M, El-Kady, Rania A, Katamesh, Ibrahim H, El-Borei, Ahmed F, Wahby   +4 more
openaire   +2 more sources

Conformational Properties of the Neurotoxins and Cytotoxins Isolated from Elapid Snake Venoms

Critical Reviews in Biochemistry, 1983
The review will critically assess the information available on the conformation of homologous neurotoxins and cytotoxins isolated from Elapid snakes. Particular attention will be given to the dynamics of the molecules in solution because there is the possibility that defined intramolecular rearrangements are involved at the sites of action.
R C Hider, M J Dufton
exaly   +3 more sources

Molecular cloning of serine proteases from elapid snake venoms

Toxicon, 2007
Serine proteases are widely distributed in viperid snake venoms, but rare in elapid snake venoms. Previously, we have identified a fibrinogenolytic enzyme termed OhS1 from the venom of Ophiophagus hannah. The results indicated that OhS1 might be a serine protease, but there was no structural evidence previously.
Yang, Jin, Wen-Hui, Lee, Yun, Zhang
openaire   +2 more sources

Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids

Biochimie, 2006
The venom from Australian elapid snakes contains a complex mixture of polypeptide toxins that adversely affect multiple homeostatic systems within their prey in a highly specific and targeted manner. Included in these toxin families are the recently described venom natriuretic peptides, which display similar structure and vasoactive functions to ...
St Pierre, Liam, Flight, Simone M., Masci, Paul P., Hanchard, Kim J., Lewis, Richard J., Alewood, Paul F., De Jersey, John, Lavin, Martin F.   +7 more
openaire   +5 more sources

Structure–function properties of venom components from Australian elapids

Toxicon, 1999
A comprehensive review of venom components isolated thus far from Australian elapids. Illustrated is that a tremendous structural homology exists among the components but this homology is not representative of the functional diversity. Further, the review illuminates the overlooked species and areas of research.
openaire   +4 more sources

The preparation of 3-nitrotyrosyl derivatives of three elapid venom cardiotoxins

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1980
Nitration studies using tetranitromethane were conducted on the tyrosine residues of cardiotoxins, naja melanoleuca VII1, Naja haje annulifera VII1 and Hemachatus haemachates toxin 12B. Various partially and fully nitrated derivatives were formed. Analysis of the products of nitrating naja melanoleuca VII1 showed that the average relative reactivities ...
openaire   +2 more sources

The selective S-alkylation of a methionine residue in an elapid venom cardiotoxin

International Journal of Biochemistry, 1987
1. The reaction of cardiotoxin with iodoacetamide or iodomethane at pH 3.0 afforded the corresponding methionine sulphonium derivatives. The major products were S-alkylated at Met-26 whilst the minor products were S-alkylated at both Met-24 and -26. 2. Reaction with iodoacetamide under denaturing conditions led to a reversal of the relative abundances ...
openaire   +2 more sources