Results 141 to 150 of about 115,118 (303)

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization

, 2012
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract.
Gill, Navkiran, Antunes, L. Caetano M., Hartmann, Martin, Al-Zahrani, Fatimah, Finlay, B. Brett, Sekirov, Inna, Willing, Benjamin P., Ferreira, Rosana B. R.   +7 more
core   +1 more source

Elastase mediated fibrinolysis in acute promyelocytic leukemia

, 2000
The bleeding syndrome of acute promyelocytic leukemia (APL) is complex and consists of disseminated intravascular coagulation (DIC) and hyperfibrinolysis.
Fijnheer, R., Bos, R., Oudijk, E.J.D., Nieuwenhuis, H.K.   +3 more
core   +2 more sources

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

Urinary elastase 1 in chronic pancreatic disease

, 1989
Serum and urine elastase 1, its renal output and clearance and urinary gamma-glutamyltransferase and ribonuclease excretions were measured in 16 patients with pancreatic cancer, 23 with chronic pancreatitis and in 22 healthy controls in order to evaluate
M. P. Panozzo, D. Basso, C. Fabris, C. Angonese, CAVALLINI, Giorgio, G. Del Favero, VANTINI, Italo, T. Meggiato, P. Fogar, BENINI, Luigi   +9 more
core   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Dermaval™ inhibits glucose-induced neutrophil elastase activity in healthy subjects

, 2013
Tania Reyes-Izquierdo,1 Boris Nemzer,2 Ruby Argumedo,1 Cynthia Shu,1 Zb Pietrzkowski1 1Applied BioClinical Inc., Irvine, CA, 2FutureCeuticals Inc, Momence, IL, USA Background: Dermaval™ is a composite formulation of various phytochemical-rich ...
Shu C, Reyes-Izquierdo T, Pietrzkowski Z, Nemzer B, Argumedo R   +4 more
core  

Elastase inhibition assays.

, 2015
(A) Baseline elastase (0.2 μg/mL) activity with N-succinyl-(l-alanine)3-p-nitroanilide (0.27 mM). Inhibition of elastase with (B) Roche protease inhibitor cocktail (60 μg/mL), (C) TFP4 (2 μg/mL), and (D) crude protein extract (1.2 μg/mL) from the defense
Roger A. Laine (739703), Youzhong Guo (739699), Gregg Henderson (739702), Octavia Y. Goodwin (739701), Thomas P. Garner (739700), Horia Negulescu (739698), Megan A. Macnaughtan (739704)   +6 more
core   +1 more source

Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis. [PDF]

Am J Respir Crit Care Med, 2020
Kim MD, Baumlin N, Yoshida M, Polineni D, Salathe SF, David JK, Peloquin CA, Wanner A, Dennis JS, Sailland J, Whitney P, Horrigan FT, Sabater JR, Abraham WM, Salathe M.   +14 more
europepmc   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source