Results 71 to 80 of about 62,911 (266)

Radioimmunoassay of Plasma Elastase

Experimental Biology and Medicine, 1974
SummaryA radioimmunoassay system was developed for the measurement of canine elastase. The method is able to measure elastase in plasma in concentrations ranging from 0.1 to 2.0 μg/ml. No cross-reactivity was found with trypsin or chymo-trypsin. The elastase levels in canine plasma were measured during experimental pancreatitis. Within 15 min after the
J, Carballo, K, Kasahara, H E, Appert, J M, Howard   +3 more
openaire   +2 more sources

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, EarlyView.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Processing of Factor XII during Inflammatory Reactions

Frontiers in Medicine, 2016
The contact system was originally identified as an obsolete part of the coagulation system, but it has been repeatedly implicated in inflammatory states, such as infection, as well as in allergic- and chronic inflammatory disease. Under these conditions,
Bernard Nico Jukema, Steven de Maat, Coen Maas   +2 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Elastase inhibition by natural flavonoids: mechanistic insights and potential therapeutic applications

Frontiers in Nutrition
Overproduction of elastase plays an important role in the progression of inflammatory diseases. In this study, we compared the inhibitory effects of structurally similar bioactive flavonoids (quercetin, hyperoside, luteolin, and luteoloside) on elastase ...
Lihao Lin, Hongliu Yao, Jinfeng Fu, Wenhui Zhang, Yongxue Li, Yan Wang, Haoyu Shen, Jingang Mo, Yi Guan   +8 more
doaj   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Bioactive Compounds from a Gorgonian Coral <em>Echinomuricea</em> sp. (Plexauridae)

Marine Drugs, 2012
A new labdane-type diterpenoid, echinolabdane A (<strong>1</strong>), and a new sterol, 6-<em>epi</em>-yonarasterol B (<strong>2</strong>), were isolated from a gorgonian coral identified as <em>Echinomuricea</
Jih-Jung Chen, Wei-Hsien Wang, Ping-Jyun Sung, Jan-Jung Li, Tsong-Long Hwang, Mei-Chin Lu, Lee-Shing Fang, Yang-Chang Wu, Hsu-Ming Chung, Pei-Han Hong, Jui-Hsin Su   +10 more
doaj   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Spontaneous Breathing Through Increased Airway Resistance Augments Elastase-Induced Pulmonary Emphysema

International Journal of COPD, 2020
Dimitrios Toumpanakis,1,2 Eleftheria Mizi,1 Vyronia Vassilakopoulou,1 Maria Dettoraki,1 Athanasia Chatzianastasiou,1 Fotis Perlikos,1 Georgia Giatra,2 Marina Moscholaki,1 Stamatios Theocharis,3 Theodoros Vassilakopoulos1,2 1“Marianthi Simou&rdquo ...
Toumpanakis D, Mizi E, Vassilakopoulou V, Dettoraki M, Chatzianastasiou A, Perlikos F, Giatra G, Moscholaki M, Theocharis S, Vassilakopoulos T   +9 more
doaj