Results 81 to 90 of about 115,118 (303)

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Previous COVID-19 infection significantly reduces elastase levels in newly diagnosed pulmonary tuberculosis patients

Frontiers in Immunology
IntroductionTuberculosis (TB) is considered a risk factor for severe COVID-19 disease and the quality of life of patients co-infected with COVID-19 and TB is significantly impacted due to the nature of these diseases.
Nancy Hilda Joseph, Alangudi Palaniappan Natarajan, Saravanan Natarajan, Chinnaiyan Ponnuraja, Madeshwaran A, Gunaparvathy I, Hemalatha P, Rajeshwari S, Lavanya Jayabal, Mahilmaran Ayyamperumal, Ramesh P. M., Luke Elizabeth Hanna   +11 more
doaj   +1 more source

Triterpenoids as Neutrophil Elastase Inhibitors

Natural Product Communications, 2015
Neutrophile elastase has the capacity to degrade elastin, a protein found in the connective tissue of the lungs. Unchecked elastase leads to pulmonary pathologies.
Dom Guillaume, Thi Ngoc Tram Huynh, Clément Denhez, Kim Phi Phung Nguyen, Azzaq Belaaouaj   +4 more
doaj   +1 more source

Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation

Scientific Reports, 2016
In Duchenne muscular dystrophy, progressive loss of muscle tissue is accompanied by fibrosis, chronic inflammation and reduced muscle regenerative capacity.
N. Arecco, Christopher J. Clarke, F. K. Jones, Deborah M. Simpson, D. Mason, Robert J. Beynon, A. Pisconti   +6 more
semanticscholar   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Trichophyton rubrum Phenotypic Virulence Factors in Mexican Strains

Biology
(1) Background: T. rubrum is the most important agent in tinea pedis, tinea manuum, tinea cruris, tinea corporis, and even in subcutaneous dermatophytosis. T.
Esther Conde-Cuevas, Rigoberto Hernández-Castro, Claudia Erika Fuentes-Venado, Roberto Arenas, María Guadalupe Frías-De-León, Gabriela Moreno-Coutiño, María Esther Ocharan-Hernández, Eunice D. Farfan-Garcia, Rodolfo Pinto-Almazán, Erick Martínez-Herrera   +9 more
doaj   +1 more source

The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease

Respiratory Research, 2000
Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allow them to efficiently inhibit target enzymes,
Sallenave Jean-Michel
doaj   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells

Cell Reports Medicine
Summary: Recent clinical studies highlight the effectiveness of combining cytotoxic agents with immunotherapies, emphasizing the need for next-generation treatments that integrate both therapeutic approaches.
Ravindra Gujar, Chang Cui, Maria Fumagalli, Nicole Martinez, Afshin Bahador, Alain Algazi, Kevin Harrington, Court Turner, Lev Becker   +8 more
doaj   +1 more source

Cosmeceutical Properties of Two Cultivars of Red Raspberry Grown under Different Conditions

Cosmetics, 2018
Plant selection, input, and field management are proven strategies that produce high yields of crops bearing selected desirable characteristics for the nutraceutical and cosmeceutical industry.
Maria Papaioanou, Evangelia G. Chronopoulou, Gheorghii Ciobotari, Rodica C. Efrose, Liliana Sfichi-Duke, Marianna Chatzikonstantinou, Evangelia Pappa, Ioannis Ganopoulos, Panagiotis Madesis, Irini Nianiou-Obeidat, Taofen Zeng, Nikolaos E. Labrou   +11 more
doaj   +1 more source