Results 101 to 110 of about 115,118 (303)

Processing of Factor XII during Inflammatory Reactions

Frontiers in Medicine, 2016
The contact system was originally identified as an obsolete part of the coagulation system, but it has been repeatedly implicated in inflammatory states, such as infection, as well as in allergic- and chronic inflammatory disease. Under these conditions,
Bernard Nico Jukema, Steven de Maat, Coen Maas   +2 more
doaj   +1 more source

Neutrophils mediate insulin resistance in high fat diet fed mice via secreted elastase

Nature Medicine, 2012
Chronic low-grade adipose tissue and liver inflammation is a major cause of systemic insulin resistance and is a key component of the low degree of insulin sensitivity that exists in obesity and type 2 diabetes. Immune cells, such as macrophages, T cells,
Saswata Talukdar, D. Oh, G. Bandyopadhyay, Dongmei Li, Jianfeng Xu, Joanne C. McNelis, Min Lu, Pingping Li, Qing-Yun Yan, Yi-Min Zhu, Jachelle M. Ofrecio, Michael Lin, M. Brenner, J. Olefsky   +13 more
semanticscholar   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Elastase inhibition by natural flavonoids: mechanistic insights and potential therapeutic applications

Frontiers in Nutrition
Overproduction of elastase plays an important role in the progression of inflammatory diseases. In this study, we compared the inhibitory effects of structurally similar bioactive flavonoids (quercetin, hyperoside, luteolin, and luteoloside) on elastase ...
Lihao Lin, Hongliu Yao, Jinfeng Fu, Wenhui Zhang, Yongxue Li, Yan Wang, Haoyu Shen, Jingang Mo, Yi Guan   +8 more
doaj   +1 more source

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

Nature Medicine, 2015
Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide
L. Vicuña, David E. Strochlic, Alban Latremoliere, K. Bali, Manuela Simonetti, Dewi Husainie, S. Prokosch, Priscilla Riva, R. Griffin, C. Njoo, Stefanie M. Gehrig, M. Mall, B. Arnold, M. Devor, C. Woolf, S. Liberles, M. Costigan, R. Kuner   +17 more
semanticscholar   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Intra-peritoneal free elastase in CAPD peritonitis [PDF]

, 1993
Intra-peritoneal free elastase in CAPD peritonitis. Neutrophil (PMN) recruitment into the peritoneum during acute bacterial peritonitis is an important part of the host defense barrier in CAPD patients.
Donovan, Kieron L., Pacholok, Steve, Coles, Gerald A., Williams, John D., Humes, John L.   +4 more
core   +1 more source

Betaine‐, xylitol‐, and extra virgin olive oil–based toothpaste modulates inflammation and oral nitric oxide pathway: Clinical trial in gingivitis

Journal of Periodontology, EarlyView.
Abstract Background Gingivitis is a prevalent and reversible inflammatory condition driven by microbial dysbiosis. Beyond plaque control, interest has grown in oral hygiene formulations capable of modulating inflammation while preserving key microbial functions. Extra virgin olive oil (EVOO), together with xylitol and betaine, has demonstrated clinical
Francisco Mesa, Alejandro Rodríguez‐Agurto, Marco Bonilla, Debora Rodríguez‐Vilaboa, Beatriz Rodríguez‐Vilaboa, Manuel Bravo   +5 more
wiley   +1 more source

Spontaneous Breathing Through Increased Airway Resistance Augments Elastase-Induced Pulmonary Emphysema

International Journal of COPD, 2020
Dimitrios Toumpanakis,1,2 Eleftheria Mizi,1 Vyronia Vassilakopoulou,1 Maria Dettoraki,1 Athanasia Chatzianastasiou,1 Fotis Perlikos,1 Georgia Giatra,2 Marina Moscholaki,1 Stamatios Theocharis,3 Theodoros Vassilakopoulos1,2 1“Marianthi Simou&rdquo ...
Toumpanakis D, Mizi E, Vassilakopoulou V, Dettoraki M, Chatzianastasiou A, Perlikos F, Giatra G, Moscholaki M, Theocharis S, Vassilakopoulos T   +9 more
doaj  

Bioactive Compounds from a Gorgonian Coral <em>Echinomuricea</em> sp. (Plexauridae)

Marine Drugs, 2012
A new labdane-type diterpenoid, echinolabdane A (<strong>1</strong>), and a new sterol, 6-<em>epi</em>-yonarasterol B (<strong>2</strong>), were isolated from a gorgonian coral identified as <em>Echinomuricea</
Jih-Jung Chen, Wei-Hsien Wang, Ping-Jyun Sung, Jan-Jung Li, Tsong-Long Hwang, Mei-Chin Lu, Lee-Shing Fang, Yang-Chang Wu, Hsu-Ming Chung, Pei-Han Hong, Jui-Hsin Su   +10 more
doaj   +1 more source